山梨酸钾的毒理学评价  

Study on the toxicity of potassium sorbate

作　　者：曾婷[1] 谢逸欣[1] 马丽[1] 

机构地区：[1]广州军区疾病预防控制中心,广东广州510507

出　　处：《海南医学》2012年第19期19-21,共3页Hainan Medical Journal

摘　　要：目的研究山梨酸钾的毒性,评价其安全性。方法按照GB15193.1-21《食品安全性毒理学评价程序》的方法对山梨酸钾的毒性级别、遗传毒性等进行安全性评价。结果山梨酸钾对小鼠急性毒性实验LD50=1300mg/kg,属低毒级;通过骨髓细胞微核试验、小鼠精子畸形试验、传统致畸试验,发现山梨酸钾无遗传毒性;30d喂养试验对动物体重、血液常规及血清ALT、BUN、GLU、TC、TG均未有明显毒性作用(P>0.05)。结论山梨酸钾是一种安全、相对无毒的食品添加剂,可用于各类食品及饮料中。Objective To investigate the general toxicity of potassium sorbate, and evaluate its security. Methods According to the standards of the People＇ s Republic of China ＂Procedures and Methods for Toxicological Assessment on Food Safety＂ （GB15193.1-21）, the toxic level, hereditary toxicity, long-term toxicity and security of potassium sorbate were evaluated. Results The LD^0 of potassium sorbate was 1 300 mg/kg, which belongs to low-toxic degree. In bone marrow cell mieronucleus, mice sperm abnormality test, teratogenicity study, thirty days feeding study, there were no genetic toxicity and dramatically changes between the experimental groups and the con- trol group for body weight, blood routine examination, and the respective levels of ALT, BUN, GLU, and TC, TG in serum （P〉0.05）. Conclusion Potassium sorbate is a kind of safe, non-toxic additive for food, which could be used in kinds of food and beverage.

关 键 词：山梨酸钾 小鼠 毒理学 安全性 评价 

分 类 号：R155[医药卫生—营养与食品卫生学]