Cyclin D1过度表达与食管癌预后关系的Meta分析  

A meta-analysis of cyclin D1 and its impact on the prognosis of esophageal cancer patients

作　　者：宋建元[1] 徐本华[1] 陈明秋[1] 郭锦华[1] 郭玉燕[1] 

机构地区：[1]福建医科大学附属协和医院放疗科,福州350001

出　　处：《中国卫生检验杂志》2012年第9期2188-2191,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨Cyclin D1过度表达与食管癌预后关系。方法:检索PubMed数据库、中国知网、维普资讯中文数据库及中国生物医学文献中文数据库,应用Meta分析软件RevMan5.1对各研究数据进行统计处理,计算合并OR值及95%可信区间(95%CI)。结果:共有19篇文献纳入系统评价,三年生存率合并OR值为0.42(95%CI:0.27-0.65);五年生存率合并OR值为0.37(95%CI:0.26-0.52)。结论:Cyclin D1过度表达与食管癌的预后有关,但该结论尚需进一步的大规模临床试验加以验证。Objective：To evaluate the significance of Cyclin D1 protein expression in prognosis of esophageal cancer.Methods： According to inclusion and exclusion criteria,articles were selected from medical electronic databases searching,including PubMed,VIP,CNK I and CBM.The odds ratio（OR） and the 95% confidence interval（CI） were also collected.Meta-analysis was completed using software Review Manager 5.1.Results： Nineteen clinical trials were included.The combined OR estimate of 3-year survival rates of patients with esophageal cancers is 0.42（95%CI,0.27-0.65）,and the combined OR estimate of 5-year survival rates of patients with esophageal cancers is 0.37（95%CI：0.26-0.52）.Conclusion： The high level of Cyclin D1 appears to be an independent prognostic factor of patients with esophageal cancers.Additional studies with large patient number and widely accepted practical methods are required to derive the precise prognostic significance of Cyclin D1 expression in esophageal cancer patients.

关 键 词：CYCLIN D1 食管癌 预后 META分析 

分 类 号：R735.1[医药卫生—肿瘤]