螺旋藻对急性化学性肝损伤小鼠肝组织脂质过氧化作用的影响  

Effect of Spirulina Platensis on Lipid Peroxidation During Acute Chemical Liver Injury in Mice

作　　者：张小强[1] 陆琮明[1] 翟成凯[1] 

机构地区：[1]南京铁道医学院营养与食品卫生学教研室,江苏南京210009

出　　处：《南京铁道医学院学报》2000年第2期105-106,共2页Journal of Nanjing Railway Medical College

摘　　要：目的 :探讨螺旋藻对急性化学性肝损伤小鼠脂质过氧化作用的影响。方法 :采用CCl4 建立急性化学性肝损伤动物模型 ,连续 2 5d经口给予实验组小鼠螺旋藻混悬液 0 .83、1.67、2 .5 0g·kg-1,分别采用TBA比色法、DTNB比色法及黄嘌呤氧化酶法测定肝组织匀浆中丙二醛 (MDA)、谷胱甘肽 (GSH )和超氧化物歧化酶 (SOD)水平。结果　实验组小鼠肝组织MDA含量降低 ,GSH和SOD水平升高 ,与阴性及模型对照组相比较具有显著性差异。结论Objective The aim of the experiment was to study the inhibitory effect of spirulina platensis on lipid peroxidation during acute chemical liver injury in mice.Method The model of CCl 4?intoxication mice was used.Result A decreased MDA activity,increased GSH and SOD activity of liver tissue were found in CCl 4?intoxicated mice after 0.83 g·kg -1 ,1.67?g·kg -1 ,2.50?g·kg -1 of spirulina platensis had been given orally for 25 days.Conclusion It is suggested that spirulina platensis posseses an inhibitory effect on lipid peroxidation during acute chemical liver injury in mice.

关 键 词：螺旋藻 肝组织损伤 脂质过氧化 抑制作用 

分 类 号：R977[医药卫生—药品] R965.2[医药卫生—药学]