人肝细胞癌组织CD_(54)表达与HLA-ABC、ALT和AST的相关性研究  

THE IMMUNOHISTOCHEMICAL STUDY OF CD_(54) EXPRESSION IN HUMAN HEPATOCELULAR CARCINOMA TISSUES

作　　者：翟守恒[1] 刘俊彬[2] 朱平[2] 王彦宏[2] 

机构地区：[1]解放军264医院,山西太原030001 [2]第四军医大学西京医院,陕西西安710032

出　　处：《肿瘤研究与临床》2000年第3期155-157,共3页Cancer Research and Clinic

摘　　要：目的 :探讨 CD5 4 在肝细胞癌 (HCC)组织中的表达及其在抗肿瘤免疫中的意义。方法 :应用免疫组织化学 (APA法 )技术 ,对 48例肝细胞癌组织的 CD5 4 、HL A- ABC的表达进行检测 ,并分析二者之间及 CD5 4 与血清转氨酶 (AL T和 AST)之间的相关性。结果 :77.1%(37/4 8)的 HCC组织表达 CD5 4 ;30 .0 %(12 /4 0 )的 HCC组织表达HL A- ABC。二者之间无显著相关性 (r=0 .2 88,P>0 .0 5 ) ;CD5 4 表达与 AL T(r=0 .0 15 ,P>0 .0 5 )和 AST(r=0 .10 6 ,P>0 .0 5 )间均无显著相关性。结论 :CD5 4 在 HCC组织中高度表达并不能引起有效抗肿瘤免疫应答和肝细胞免疫损伤 ,这可能与 HL A- ABC表达率较低有关。Objective:To study the expression of CD 54 in human hepatocellular carcinoma (HCC) tissues and probe into its significance in anti tumor immune response.Methods:CD 54 and HLA ABC were detected in HCC tissues with immunohistochemical methods,and the relativity between CD 54 and HLA ABC,and ALT and AST were analysed.Results:The positive rate of CD 54 was 77.1%(37/48) and HLA ABC was 30.0%(12/40) in human HCC tissues.There was no significant relativity between CD 54 and HLA ABC (r=0.228,P>0.05),and ALT(r=0.015,P>0.05), and AST (r=0.106,P>0.05) .Conclusion:CD 54 was strongly expressed in HCC,but this could not evoke effective anti tumor immune response and/or induce hepatocellular immune injury.This may be related to the lower expression rate of HLA ABC.

关 键 词：肝肿瘤 CD54 HLA-ABC 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]