Improved Method for Lacosamide Synthesis with Chemoenzymatic Method  

作　　者：WANG Zhi-yuan XU Li-sheng LIU Jun-zhong ZHANG Hong-juan GAO Ji LIU Qian JIAO Qing-cai 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,School of Life Science,Nanjing University,Nanjing 210093,P.R.China

出　　处：《Chemical Research in Chinese Universities》2012年第5期833-836,共4页高等学校化学研究（英文版）

基　　金：Supported by the National Technology-Innovation Fund(No.02CJ-13-01-16);the Open Fund of State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University, China

摘　　要：Lacosamide was prepared by chemical method coupled with enzymatic method. N-Acetyl-D, L-3-methoxy-alanine, derived from D,L-3-methoxy-alanine, was used in the resolution process catalyzed by immobilized Escherichia coli cells with aminoacylase（EC3.5.1.14） activity. N-Acetyl-D-3-methoxy-alanine and L-3- methoxy-alanine were obtained from the resolution system. Lacosamide was synthesized by the amidation of N-acetyl-D-3-methoxy-alanine with benzylamine.Lacosamide was prepared by chemical method coupled with enzymatic method. N-Acetyl-D, L-3-methoxy-alanine, derived from D,L-3-methoxy-alanine, was used in the resolution process catalyzed by immobilized Escherichia coli cells with aminoacylase（EC3.5.1.14） activity. N-Acetyl-D-3-methoxy-alanine and L-3- methoxy-alanine were obtained from the resolution system. Lacosamide was synthesized by the amidation of N-acetyl-D-3-methoxy-alanine with benzylamine.

关 键 词：LACOSAMIDE AMINOACYLASE N-Acetyl-D L-3-methoxy-alanine Immobilized cell 

分 类 号：Q55[生物学—生物化学] TQ246.3[化学工程—有机化工]