无抽搐电休克(MECT)在难治性抑郁症维持治疗中的应用  

Utilization of MECT in Maintenance Therapy in Refractory Depression Patients

作　　者：徐清[1] 周德祥[1] 张菁[1] 陆志新[1] 

机构地区：[1]中国.江苏省无锡市精神卫生中心,214151

出　　处：《中国健康心理学杂志》2012年第9期1302-1303,共2页China Journal of Health Psychology

摘　　要：目的研究联合MECT治疗难治性抑郁症急性期及维持期的疗效及安全性。方法对54例难治性抑郁症患者,在急性期及维持期联合MECT治疗,用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应,用韦氏记忆量表(WMS)进行记忆测定。结果 MECT急性期治疗后41例(75.9%)有效。急性期治疗结束后,HAMD总分下降有非常显著性差异(t=10.36,P<0.01);维持治疗8周末、16周末与治疗前比较,HAMD总分的下降均有非常显著性差异(t=17.22～20.29,P<0.01)。WMS中的再认(t=5.73,P<0.01)、图片(t=4.72,P<0.01)、联想(t=3.93,P<0.01)及背数(t=5.23,P<0.01)在急性期治疗结束后1天较治疗前评分下降有非常显著性差异,但在维持治疗前1天、维持治疗8周末、16周末、18周末较治疗前评分无显著性差异(P>0.05)。无明显不良反应。结论 MECT安全性高,对难治性抑郁症的急性和维持治疗均有效。Objective To explore the effect and tolerance of combining acute and maintenance MECT for the refractory depression.Methods A total of 54 refractory depressions patients were treated with combining acute and maintenance MECT.The effects were evaluated by HAMD and the tolerance by TESS.The memory measurement was evaluated by WMS.Results 41（75.9%）patients were effective at the end of acute MECT comparing the end with the before of acute MECT,the total scores of HAMD reduced significantly（t=10.36,P0.01）.Comparing the end of 8-week and 16-week in maintenance MECT with the before of acute MECT,the total scores of HAMD reduced significantly（t=17.22～20.29,P0.01）.The scores of recognition（t=5.73,P0.01）,the scores of picture（t=4.72,P0.01）,the scores of association（t=3.93,P0.01）,the scores of number recite（t=5.23,P0.01）decreased significantly at 1 day after the endpoint of MECT,but there was no significant difference between before and 1 day before the maintenance MECT and the end of 8,16,18week in maintenance MECT（P0.05）.There was not significant side effects.Conclusion MECT is a safe way for refractory depression.and effective in the treatment of the refractory depression not only in acute but also in maintenance therapy.

关 键 词：精神病学 无抽搐电休克治疗 难治性抑郁症 维持治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]