Vasculogenic mimicry is a key prognostic factor for laryngeal squamous cell carcinoma： a new pattern of blood supply  

作　　者：LIN Peng WANG Wei SUN Bao-cun CAI Wen-juan LI Li LU Hong-hua HAN Chun-rong ZHANG Jin-mei 

机构地区：[1]Department of Otolaryngology Head and Neck, Tianjin First Central Hospital, Tianjin Institute of Otolaryngology, Tianjin Medical University, Tianjin 300192, China [2]Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China

出　　处：《Chinese Medical Journal》2012年第19期3445-3449,共5页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China （No. 81102055）, Tianjin Natural Science Foundation （No. llJCYBJC10700） and Technology Programme of Tianjin Health Bureau （No. 2010KZ30）.

摘　　要：Background Recurrence and local lymph node metastasis affected the prognosis of patients with laryngeal cancer. The aim of this study was to analyze clinical and pathological significance of vasculogenic mimicry （VM） in laryngeal squamous cell carcinoma （LSCC） and evaluate its contribution to prognosis. Methods Data of 168 cases of LSCC were reviewed retrospectively to reveal clinical pathology and prognostic significance of VM. CD31 and periodic acid-Schiff double staining was used to identify VM. Results VM in LSCC contributed to lymph node metastasis （P=0.003） and clinical progression. VM correlated to histopathology grade （P=0.001） of LSCC. VM was an adverse prognostic factor for both disease-specific survival （P=0.039） and metastasis-free survival （P=0.042） by univariate survival analyses. And it was an independent prognostic factor for only disease-specific survival （P=0.003） by multivariate survival analyses. Conclusions VM existed in LSCC. LSCC with VM has more Dotential to invasion and metastasis.Background Recurrence and local lymph node metastasis affected the prognosis of patients with laryngeal cancer. The aim of this study was to analyze clinical and pathological significance of vasculogenic mimicry （VM） in laryngeal squamous cell carcinoma （LSCC） and evaluate its contribution to prognosis. Methods Data of 168 cases of LSCC were reviewed retrospectively to reveal clinical pathology and prognostic significance of VM. CD31 and periodic acid-Schiff double staining was used to identify VM. Results VM in LSCC contributed to lymph node metastasis （P=0.003） and clinical progression. VM correlated to histopathology grade （P=0.001） of LSCC. VM was an adverse prognostic factor for both disease-specific survival （P=0.039） and metastasis-free survival （P=0.042） by univariate survival analyses. And it was an independent prognostic factor for only disease-specific survival （P=0.003） by multivariate survival analyses. Conclusions VM existed in LSCC. LSCC with VM has more Dotential to invasion and metastasis.

关 键 词：laryngeal squamous cell carcinoma vasculogenic mimicry PROGNOSIS METASTASIS 

分 类 号：R739.65[医药卫生—肿瘤]