Perfectly Green Organocatalysis： Quaternary Ammonium Base Triggered Cyanosilylation of Aldehydes  

作　　者：温叶倩 梁梦伟 王忆铭 任伟民 吕小兵 

机构地区：[1]State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian,Liaoning 116024,China

出　　处：《Chinese Journal of Chemistry》2012年第9期2109-2114,共6页中国化学（英文版）

摘　　要：Quaternary ammonium bases, such as aqueous （CH3）4NOH, were found to be an extraordinarily efficient cata-lyst for cyanosilylation of aldehydes. The addition reaction of trimethylsilyl cyanide （TMSCN） to equivalent alde-hydes could proceed smoothly with turnover frequency （TOF） up to 3000000 h l and in near 100% yield under solvent-free conditions. These organic catalysts also tolerated various aldehydes including aromatic, aliphatic and a,fl-unsaturated aldehydes. This process perfectly conforms to the features of green chemistry： no waste regarding side-products and unconverted reactants, solvent-free, excellent catalytic activity, and no requirement for separa- tion.Quaternary ammonium bases, such as aqueous （CH3）4NOH, were found to be an extraordinarily efficient cata-lyst for cyanosilylation of aldehydes. The addition reaction of trimethylsilyl cyanide （TMSCN） to equivalent alde-hydes could proceed smoothly with turnover frequency （TOF） up to 3000000 h l and in near 100% yield under solvent-free conditions. These organic catalysts also tolerated various aldehydes including aromatic, aliphatic and a,fl-unsaturated aldehydes. This process perfectly conforms to the features of green chemistry： no waste regarding side-products and unconverted reactants, solvent-free, excellent catalytic activity, and no requirement for separa- tion.

关 键 词：ORGANOCATALYSIS green chemistry CYANOSILYLATION quaternary ammonium base SOLVENT-FREE 

分 类 号：TQ241.31[化学工程—有机化工] TQ324.9