Effect of Transcutaneous Electrical Acupoint Stimulation on Rats with Chronic Exercise-induced Fatigue  

经皮穴位电刺激对慢性运动性疲劳大鼠的影响(英文)

作　　者：方剑乔 马桂芝 梁宜 王臻 

机构地区：[1]Zhejiang University of Traditional Chinese Medicine

出　　处：《Journal of Acupuncture and Tuina Science》2012年第5期265-270,共6页针灸推拿医学（英文版）

基　　金：supported by National Natural Science Foundation of China(30572412);Top Priority Discipline of Zhejiang Province(Acupuncture-moxibustion and Tuina)

摘　　要：Objective： To observe the effect of transcutaneous electrical acupoint stimulation （TEAS） on the rats with exercise-induced fatigue. Methods： Rat model of chromic exercise-induced fatigue was established with increasing load treadmill walking method. The TEAS therapy was operated immediately and 3 h after the exercise from the sixth week. Hippocampal morphology and hypothalamic morphology were observed with HE staining and the expressions of 5-hydroxytryptamine （5-HT） in hippocampus and hypothalamus were tested with immunohistochemical （IHC） staining after 2-week treatment. Results： TEAS released the damage of hippocampal morphology and hypothalamic morphology induced by exercise significantly and reduced the expression of 5-HT in hippocampus and hypothalamus. The difference between the therapy operated immediately and 3 h after exercise was not significant. Conclusion： TEAS could improve the fatigue recovery and athletic ability. The improvement of TEAS on the rats with exercise-induced fatigue was related with the decreased expression of central 5-HT and the reduction of damaged nerve cells.目的:观察经皮穴位电刺激(Transcutaneous Electrical Acupoint Stimulation,TEAS)对运动性疲劳大鼠的影响。方法:采用递增负荷跑台法建立大鼠慢性运动性疲劳模型,第6星期开始,分别在运动后即刻和3h后进行TEAS治疗。治疗2星期后,HE染色观察大鼠海马、下丘脑组织形态学变化,免疫组化法观察海马、下丘脑5-羟色胺(5-hydroxytryptamine,5-HT)的表达。结果:TEAS可以明显减轻运动引起的大鼠海马、下丘脑组织形态损伤,降低大鼠海马、下丘脑5-HT表达,运动后即刻治疗和3h后治疗的两组间无统计学差异。结论:TEAS有促进疲劳恢复,提高运动能力的作用。TEAS改善大鼠的运动性疲劳状态与降低中枢5-HT表达、减少神经细胞损伤有关。

关 键 词：Acupoint Therapy Muscle Fatigue SEROTONIN HIPPOCAMPUS HYPOTHALAMUS RATS 

分 类 号：R2-03[医药卫生—中医学]