两个新型4-羟基-3-喹啉羧酸酯类抗球虫化合物的合成  

Synthesis of Two Novel 4-Hydroxy-3-Quinolinecarboxylates Anticoccidial Compounds

作　　者：严春蓉[1,2] 李兰[2] 吴凯群[1] 王玉良[1] 

机构地区：[1]四川大学化学学院,四川成都610064 [2]宜宾学院化学与化工学院,四川宜宾644000

出　　处：《宜宾学院学报》2012年第6期47-49,共3页Journal of Yibin University

基　　金：国家自然科学基金项目(21072135);宜宾学院博士科研启动基金项目(2010B09)

摘　　要：经过亚硝化、催化加氢、缩合、醚化和关环等五步反应,设计并合成了两个新型4-羟基-3-喹啉羧酸酯类抗球虫化合物.新化合物的合成具有合成路线短、产率高、原料易得、易实现工业化等优点.所有化合物的结构均经1H NMR,IR和HRMS等方法确证.Two novel 4-hydroxy-3-quinolinecarboxylates anticoccidial compounds were designed and synthesized through five-step reactions of nitrification,catalytic hydrogenation,condensation,etherification and closed loop response.The new process is characterized by a short synthetic route,high yield and cheap raw material,which is convenient for the commercial production.The structures of these compounds are confirmed by 1H NMR,IR spectra and HRMS.

关 键 词：4-羟基-3-喹啉羧酸酯类抗球虫化合物 合成 亚硝化 催化加氢 缩合 醚化 关环 

分 类 号：G633.8[文化科学—教育学]