番茄红素对小鼠前胃癌的保护作用  

The protection of lycopene on the forestomach neoplasm in mice

作　　者：肖白曼[1] 陈文华[2] 刘培培[2] 潘洪志[2] 遇晓杰[1] 

机构地区：[1]黑龙江省疾病控制中心,哈尔滨150030 [2]哈尔滨医科大学公共卫生学院,哈尔滨150081

出　　处：《中国卫生检验杂志》2012年第10期2344-2346,共3页Chinese Journal of Health Laboratory Technology

基　　金：黑龙江省自然科学基金(D200628)

摘　　要：目的:观察番茄红素对小鼠前胃组织癌变过程的影响及其作用机制。方法:昆明小鼠随机分成4组,番茄红素组分别饲喂高、中、低不同剂量的番茄红素饲料,模型组饲喂正常饲料,2周后灌喂含苯并(a)芘的色拉油,24周后处死全部动物,观察小鼠前胃癌形成情况,测定血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GSH-Px)活性、总抗氧化活力(T-AOC)、丙二醛(MDA)和还原型谷胱甘肽(GSH)含量。结果:与模型组相比,番茄红素高剂量组成瘤率和瘤直径显著减小,MDA含量降低,CAT、GSH-Px活力明显升高,高、中剂量组SOD、T-AOC活性升高。结论:番茄红素具有抑制肿瘤生长的作用,其作用机制可能与提高抗氧化酶活力,降低脂质过氧化产物有关。Objective：To observe the role of lycopene in forestomach carcinogenesis process in mice, to explore its possible mechanism of action. Methods： Kunming mice were randomly and equally divided into 4 groups ： lyco- pene groups were fed with high, medium and low doses of lycopene, the model group was fed with normal diet. After 2 weeks, all animals were fed with salad oil consisting of benzo （eL） pyrene and put to death after 24 weeks. The effects of different concentrations of lycopene on the formation of forestomach neoplasm in mice were studied by measuring theactivity of superoxide dismutase （SOD）, catalase （CAT）, glutathione peroxidase （GSH- Px）, total antioxidant （T - AOC） and levels of malondialdehyde （MDA） and glutathione （GSH） in serum. Results ： The tumor were found in all groups and confirmed by pathology. Compared with model group, high - dose lycopene tumor rates and tumor diameter were significantly reduced （P 〈 0.05 ）. At the same time, the level of MDA in the high dose group decreased （P 〈0.01 ）, but the activity of CAT and GSH -＇Px increased, and the difference was signifi- cant. Compared with model group, the activity of SOD and T - AOC were significantly higher in high - dose and middle - dose lycopene groups. Conclusion： Lycopene can inhibit growth of tumor and the mechanism may be re- lated to its action of increasing activity of antioxidant enzyme and reducing lipid peroxidation.

关 键 词：番茄红素 胃癌 苯并芘 抗氧化 

分 类 号：R735.2[医药卫生—肿瘤]