山西省食管癌患者出生顺序研究  

Study on the birth order of patients with esophagus cancer in Shanxi province

作　　者：韩斐[1] 范亚峰[1] 王国平[1] 丁悌[1] 李建民[1] 苏文[2] 高泽锋[1] 韩小友[2] 

机构地区：[1]山西省肿瘤医院,太原030013 [2]山西省肿瘤研究所

出　　处：《中华流行病学杂志》2012年第11期1127-1129,共3页Chinese Journal of Epidemiology

基　　金：a grant from the Shanxi Provincial Tumor Hospital and National Cancer Institute (NCI) Upper Gastrointestinal Cancer Genetics Research Subject，本研究资料来源于山西省肿瘤医院与美国国立癌症研究所上消化道癌遗传学研究课题

摘　　要：目的分析山西省食管癌患者的出生顺序，探讨环境因素、遗传因素与食管癌的关系。方法采用Greenwood和Haldane的出生顺序方法，以山西省肿瘤医院1101例住院食管癌手术患者为先证者进行遗传流行病学调查，并对1101例先证者及44例食管癌患病同胞进行出生顺序研究。结果Greenwood法分析结果显示，食管癌患者较多发生在出生顺序1-3胎次。Haldane法计算6A实际值=17118，6A理论平均值X=19290，代入X=｜6A-X6A｜/√V6A=7．63（X〉2），差异有统计学意义（P〈0．01），表明胎次对食管癌发生具有效应。另外，6A实际值〈6A理论平均值，表明父母育龄小或先出生的胎儿易患食管癌。结论环境因素对食管癌的发生有一定的影响。食管癌的发生与出生顺序有关，易发生在出生胎次较早的个体，这与国内其他食管癌出生顺序研究结果不一致。Objective To explore the relationship between esophagus cancer patients and both environmental and genetic factors, through analyzing the data on birth orders from esophagus cancer patients of Shanxi province. Methods Both Greenwood and Haldane methods on birth order were used to study the 1101 cases with esophagus cancer from Shanxi province. All the patients had received surgery and were diagnosed, by pathological evidence. First certificates of the patients were confirmed through the standard genetic epidemiologic investigation. Birth order was investigated on probands of the 1101 cases with esophagus cancer and their 44 siblings. Results Results form the Greenwood method showed that there was a tendency for cases with esophagus cancer in birth orders First to Third. However, the Haldane method showed that the results were quite different between actual value and the average theory value of 6A （6A（actual value）=17 118,X6A（average theory value）= 19 290, X=｜6A-X6A｜/√V6A=7.63（X〉2） which suggested that the birth order had some effects on the occurrence of esophagus cancer. In addition, the actual value of 6A was lower than the theoretic average value, and the parents at younger productive age or baby at the first birth was easy to develop esophagus cancer. Conclusion Esophagus cancer was related with the birth order, especially at early order, which was not consistent with the national reports on esophagus cancer. Results from this study suggested that there were certain effects of environmental risk factors on esophagus cancer patients.

关 键 词：食管肿瘤 出生顺序 家系研究 

分 类 号：R735.1[医药卫生—肿瘤]