Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography  

作　　者：Marie-Josée Rocheleau Elaine Larouche Cristina Salamu Mihaela Curca 

机构地区：[1]Omega Laboratories Ltd.,11177 Hamon,Montréal,QC H3M 3E4,Canada

出　　处：《Journal of Pharmaceutical Analysis》2012年第5期372-377,共6页药物分析学报（英文版）

摘　　要：Liquid chromatography （LC） is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past several years, small particle size packing materials have been introduced by several column manufacturers to enable fast and efficient LC separations. Several examples of pharmaceutical analyses, including impurity profiling of taxanes and atracurium besylate, in-process testing of peptides in injectable dosage form, using sub-2 um column technology are presented in this paper, demonstrating some of the capabilities and limitations of the technology.Liquid chromatography （LC） is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past several years, small particle size packing materials have been introduced by several column manufacturers to enable fast and efficient LC separations. Several examples of pharmaceutical analyses, including impurity profiling of taxanes and atracurium besylate, in-process testing of peptides in injectable dosage form, using sub-2 um column technology are presented in this paper, demonstrating some of the capabilities and limitations of the technology.

关 键 词：Liquid chromatography UPLC PHARMACEUTICAL TAXANE Atracurium besylate PEPTIDES 

分 类 号：R927.2[医药卫生—药学]