脂肪酶催化合成L-抗坏血酸脂肪酸酯和D-异抗坏血酸脂肪酸酯  

Lipase-catalyzed synthesis of L-ascorbyl fatty acid esters and D-isoascorbyl fatty acid esters

作　　者：郑大贵[1] 祝显虹[2] 余泗莲[3] 彭化南[1] 张小兰[1] 

机构地区：[1]上饶师范学院江西省普通高校应用有机化学重点实验室,江西上饶334001 [2]南昌大学化学系,江西南昌330031 [3]百勤异VC钠有限公司,江西德兴334221

出　　处：《化学研究与应用》2012年第11期1752-1757,共6页Chemical Research and Application

基　　金：江西省普通高校重点实验室科技计划项目(GJJ08523号)资助;江西省科技条件平台建设项目(2010DTZ01900)资助

摘　　要：用固定化脂肪酶Lipozyme 435作催化剂,分别用直接酯化法和酯交换法合成L-抗坏血酸脂肪酸酯和D-异抗坏血酸脂肪酸酯。产物结构经IR、1HNMR、13CNMR和MS表征。结果表明,对于同一目标化合物,相似条件下,直接酯化法的效果优于酯交换法,原料脂肪酸和脂肪酸甲酯均可回收循环使用。The lipase-catalyzed synthesis of L-ascorbyl fatty acid esters and D-isoascorbyl fatty acid esters were studied by direct es- terification and transesterification, respectively. The structures of products were confirmed by IR, 1H NMR, 13C NMR and MS. It was found that the yield of the direct esterification were higher than that of the corresponding transesterification under the similar syn- thetic conditions. The raw material fatty acids and fatty acid methyl esters could be recycled and reused.

关 键 词：脂肪酶 直接酯化法 酯交换法 L-异抗坏血酸脂肪酸酯 D-异抗坏血酸脂肪酸酯 

分 类 号：TS201.2[轻工技术与工程—食品科学]