药用黄腐酸的纯化工艺研究  

Study on the purification technology of medicinal fulvic acid

作　　者：张惠芬[1] 秦谊[2] 何静[2] 刘建珍[2] 李敏[2] 李宝才[2] 

机构地区：[1]昆明理工大学化学工程学院,云南昆明650500 [2]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《食品工业科技》2012年第22期296-298,302,共4页Science and Technology of Food Industry

基　　金：国家自然科学基金项目(21166013)

摘　　要：建立了001×7型阳离子交换树脂纯化黄腐酸(FA)的工艺,通过对工艺参数的考察,确定优化工艺条件为:树脂用量:FA用量(体积重量比,mL/g)为25:1;离子交换时间为140min;冷冻干燥。用该工艺制备的FA精制品灰分均在1%以下,其中有害元素As的含量为0.31mg/kg,Cd含量在0.1mg/kg以下,Hg含量在0.05mg/kg以下,Pb和Cr含量均在0.5mg/kg以下,其纯度和有害元素含量均达到了药用和食用的级别。同时,FA经纯化后,活性相对增强。本研究所建立的新工艺简单有效,且经济成本较低,为FA精制品的制备提供了技术保障,也能为其在医药、功能性食品等领域的应用提供安全保障。Purification technology of medicinal fulvic acid（FA） was established by 001×7 cation exchange resin.According to the investigation of technological parameters,the optimized technical conditions were obtained as fallows：the ratio of resin usage amount to FA usage amount was 25∶1（volume-weight ratio,mL/g）.The ion exchange time lasted for 140min.Then freeze drying.The ash content of the refined FA prepared through this technology was all less than 1%,in which the content of As was 0.31mg/kg,Cd below 0.1mg/kg,Pb and Cr below 0.5mg/kg,and Hg below 0.05mg/kg.The purity and contents of harmful elements of the refined FA both reached to medicinal and edible levels.Meanwhile,the activity of refined FA was relatively enhanced by purification.The new technology,which was simple,effective and lower cost,not only provided technical support for the preparation of refined FA,but also provided security for the application of FA in the fields of medicine and functional food.

关 键 词：黄腐酸 离子交换 纯化 工艺条件 

分 类 号：TS201.2[轻工技术与工程—食品科学]