1-(4-羟基苯基)哌嗪氢溴酸盐的合成  

Synthesis of 1-(4-Hydroxyphenyl) Piperazine Hydrobromide

作　　者：付晓钟[1] 张珏[1] 袁牧[1] 刘香[1] 张敏[1] 胡伦香[1] 

机构地区：[1]贵阳医学院药物研究室,贵阳550004

出　　处：《贵阳医学院学报》2000年第1期4-6,共3页Journal of Guiyang Medical College

基　　金：贵州省科技基金!资助课题 (计 9610 74)

摘　　要：以 β ,β′ 二氯代二乙基胺盐酸盐为起始原料 ,经与对甲氧基苯胺环合反应而得到 1 (4 甲氧苯基 )哌嗪盐酸盐 ,后者经 37%HB与醋酐 (V/V1∶1)回流反应脱去甲基 ,得到 1 (4 羟基苯基 )哌嗪氢溴酸盐 ,将所得产物用红外光谱测定结构 ,通过标准图谱对照 ,证实合成的化合物与目标化合物结构一致。In order to synthesiye 1 (4 Hydroxyphenyl) piperazine hydrobromide, Bis-2-chloro-ethylamine hydrochloride was used as initial material by cyclizative condensation with p-Aminoanisole to get 1 (4 Methoxyphenyl) piperazine hydrochloride, which was demethylated by heating to reflux in aqueous of 37% HBr and Acetic anhydride (V/V1∶1) to afford the corresponding p-Hydroxy derivative. The synthesized compound was identified with IR spectra. The result showed it was consistent with the proposed structure.

关 键 词：脱甲基化 合成 红外光谱法 苯基哌嗪类 

分 类 号：R914.5[医药卫生—药物化学]