牛磺酸对大鼠杏仁核点燃的作用  

EFFECT OF TAURINE ON THE AMYGDALAKINDLING IN RATS

作　　者：王蕾[1] 岳旺[1] 刘占涛[1] 臧东莲[1] 

机构地区：[1]青岛大学医学院药理教研室,青岛266021

出　　处：《中国海洋药物》2000年第1期14-16,共3页Chinese Journal of Marine Drugs

基　　金：山东省卫生厅科研基金!资助课题 (批准号 :950 39)

摘　　要：用大鼠杏仁核点燃模型 (Kindling model) ,研究牛磺酸对点燃发展进程及完全点燃的大鼠的作用。每日一次电刺激大鼠右侧杏仁核 (40 u A、60 HZ、波宽 1 ms、矩形方波 1秒 ) ,在 1 3次产生点燃效应的 V期反应 ,刺激后放电时间显著延长。脑室注射牛磺酸 2 0 0 ug、40 0 ug可显著抑制眯燃效应的 V期反应 (P<0 .0 1 ) ,但对已点燃的大鼠无抑制作用。提示牛磺酸作为内源性的氨基酸神经递质 ,在预防癫痫的发展方面有重要作用。To study the effects of taurine on amygdala kindling development and kindled seizures in rats. Electrical stimulation of the right amygdala (400uA, 60Hz, square wave for one sec) was given one time a day. An average of daily consecutive 13 stimulations was needed to reach the rirst V stage seizures, at which the rats showed behaviorial convulsions and electroencephalographic abnormalities. Intraceretroven-triculal injection of taurine (200ug, 400ug) significantly inhibited the amygdala kindling development (P<0.01),but no effect on fully kindled rats. It suggested that taurine had played an important role in preventing the forming and development of neurosis related to epilepsy.

关 键 词：牛磺酸 点燃模型 大鼠 杏仁核 癫痫 

分 类 号：R742.105[医药卫生—神经病学与精神病学] R977.4[医药卫生—临床医学]