食管鳞状细胞癌组织中EGFR、GST-π和癌基因C-erbB-2的表达及其意义  

Expression of EGFR,GST-π and C-erbB-2 in esophageal squamous cell carcinoma and their clinical significance

作　　者：强勇[1] 徐艳辉[1] 李忠东[1] 钱建军[1] 景华[1] 

机构地区：[1]南京军区南京总医院心胸外科,南京210002

出　　处：《重庆医学》2012年第32期3377-3379,F0002,共4页Chongqing medicine

摘　　要：目的本研究观察EGFR、GST-π和C-erbB-2在216例食管鳞癌中的表达及其意义。方法收集手术食管鳞癌标本,应用EnVision法免疫组化检测EGFR、GST-π和C-erbB-2。并分别比较高分化与中、低分化组,局部浸润较浅与较深组,有与无淋巴结转移组,临床分期较早与较晚组3种基因的表达,探讨3者与食管鳞癌临床因素间的关系。结果 EGFR的表达与食管鳞癌分化程度(P=0.036)、局部浸润(P=0.022)、淋巴结转移情况(P=0.037)、临床分期(P=0.021)有相关性,GST-π和C-erbB-2的表达与局部浸润(P=0.019、0.006)、淋巴结转移情况(P=0.028、0.039)、临床分期(P=0.012、0.027)紧密相关,与分化程度(P=0.162、0.722)不相关。结论 EGFR、GST-π和C-erbB-2联合检测对判断食管鳞癌生物学行为、预后及指导治疗有重要意义。Objective To observe the expression of EGFR,GST-π and C-erbB-2 in 216 esophageal squamous cell carcinoma（ES- CC） patients. Methods We collected surgical specimens of ESCC,and applied EnVision immunohistochemical method to detect the expression of EGFR,GST-π and C-erbB-2, compared well-differentiated group and poorly differentiated group, shallow local infiltra tion group and deep group, with and without lymph node metastasis group, earlier clinical stage group and later group, then re searched the relationship between the three biochemical substances and clinical factors. Results The data indicates that the expres sion of EGFR was closely related to differentiation degree（P= 0.036）, the depth of local infiltration（P = 0. 022） ,lymph node metas- tasis（P：0. 037） and the clinical stage（P=0. 021） ;and the expression of GST-n and C-erbP,-2 were associated with depth of local infiltration （P = 0.019,0. 006）, lymph node metastasis （P = 0. 028,0. 039） and the clinical stage（P = 0. 012,0. 027） , but not associat ed with the differentiation degree（P= 0. 162,0. 722）. Conclusion Combined detection of EGFR, GST-n and C-erbB-2 can play an important role to predict the biological behaviour, prognosis and guide therapy.

关 键 词：肿瘤 鳞状细胞 食管 EGFR GST-Π C—erbB-2 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]