KEGG数据库的进展及其在生物信息学中的应用  

Recent Progress and Application of KEGG Database in the Research of Bioinformatics

作　　者：李向真[1] 刘子朋[1] 李娟[2] 方慧生[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]南京鼓楼医院血液科,江苏南京210008

出　　处：《药物生物技术》2012年第6期535-539,共5页Pharmaceutical Biotechnology

摘　　要：KEGG(Kyoto Encyclopedia of Genes and Genomes)数据库作为整合了基因、酶、化合物及代谢网络信息的综合性数据库,在生物信息学研究中提供了非常重要的平台。首先,人工获得实验数据并将其组织为计算格式,构建成一个系统功能知识体系:包括KEGG通路图,BRITE等级分类以及KEGG modules。其次,建立并完善跨物种注释步骤KO,把基因组同分子网络联系起来。文章主要介绍KEGG数据库的最新进展以及KEGG在生物信息学中的应用。KEGG特有的图形代谢通路以及KO注释,对于重构代谢网络以及跨物种的代谢网络分析提供了很好的信息,KEGG数据库在生物合成以及药物设计方面将会得到越来越广泛的应用。Kyoto Encyclopedia of Genes and Genomes （KEGG） is a database resource that integrates genomic, chemical and systemic functional information, which provides genomes and their relationships to biological systems as well as their interactions with the environment. It is a platform for bioinformatics researches. KEGG is categorized in terms of building blocks in the genomie space, known as KEGG GENES, the chemical space, KEGG LIGAND, writing diagrams of interaction and reaction networks, KEGG PATHWAY. It manually constructs a function knowledge system which contains KEGG Pathway map, BRITE functional hierarchies and KEGG Modules. Then it constructs KEGG Orthology which contacts genomes with molecular network. KEGG BRITE contains KEGG Orthology. This paper mainly introduces the latest progress of KEGG database and its application in Bioinformatics. The Pathway map and KO of KEGG database provide fruitful information on the metabolic reconstruction and the metabolic network analysis among different networks. It introduces KEGG and its functions for genomic analyses, focusing on the usage of the KEGG GENES, PATHWAY, BRITE and Mapper. In the Disease Database, each disease is represented by a list of known genes, any known environmental factors at the molecular level, diagnostic markers and therapeutic drugs, which may reflect the underlying molecular system. The Disease and Drug Database can be used as a reference base for computational analysis of molecular networks. The metabolic network can be reconstructed by using the KEGG database. KEGG database will be more and more widely used in the fields of biosynthesis and drug design.

关 键 词：代谢网络 京都基因和基因组百科全书 生物信息 代谢途径 直系同源分类 路径图 等级目录 

分 类 号：Q811.4[生物学—生物工程]