雄黄注射液安全性研究I  

Safety research of Realgar Injection I

作　　者：张爽[1] 晏磊[1] 陈志宝[1] 胡慧欣[1] 李雪[1] 

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163319

出　　处：《药物评价研究》2012年第6期451-453,共3页Drug Evaluation Research

基　　金：黑龙江省教育厅科学技术研究项目(12511361;12511362);黑龙江省青年科学基金项目(QC2009C115);黑龙江八一农垦大学科研启动基金(B2011-13)

摘　　要：目的评价雄黄注射液注射给药的安全性。方法利用小鼠对雄黄注射液进行异常毒性、急性毒性实验,鲎试剂法检测内毒素,利用家兔进行体外溶血实验。结果雄黄注射液异常毒性实验和急性毒性实验均未见小鼠死亡,且饮食、行为、运动等功能均正常。鲎试剂检查细菌内毒素结果呈阴性,对家兔红细胞无溶血和凝集作用。结论在实验条件下雄黄注射液安全性良好。Objective To evaluate the safety of Realgar Injection（RI）.Methods The abnormal toxicity test and acute toxicity test were performed in mice,endotoxin was determined by tachypleus amebocyte lysate method,and hemolysis test was performed in vitro using rabbit blood.Results In the abnormal toxicity test and acute toxicity test there were no dead of mice,and their functions of diet,behavior,and moving were normal.The result of tachypleus amebocyte lysate test was negative and there was no hemolysis and agglutination reaction in vitro.Conclusion The safety of RI used as the clinical injection is good.

关 键 词：雄黄注射液 异常毒性 急性毒性 鲎试剂法 细菌内毒素 溶血 

分 类 号：R965.3[医药卫生—药理学]