Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix  

作　　者：Rajeev Jain Ramkishor Sharma 

机构地区：[1]School of Studies in Chemistry, Jiwaji University

出　　处：《Journal of Pharmaceutical Analysis》2012年第6期443-449,共7页药物分析学报（英文版）

摘　　要：Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode （HMDE） in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 5-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL.Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode （HMDE） in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 5-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL.

关 键 词：GRANISETRON Human plasma Solid-phase extraction Pharmaceuticalformulation VOLTAMMETRY Hanging mercury dropelectrode 

分 类 号：R914[医药卫生—药物化学]