旧基因,新功能——乳铁蛋白参与抑制肿瘤生长和转移  

New function of lactoferrin: protection against cancer development and metastasis

作　　者：郑瑛[1,2] 陈攀[1] 郭小芳[1] 马健[1] 李桂源[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078 [2]中南大学湘雅二医院医学实验研究中心,长沙410013

出　　处：《中南大学学报（医学版）》2012年第12期1284-1289,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(81071756;81171988)~~

摘　　要：乳铁蛋白(lactoferrin,LF)是一种分子质量约为80 kD的铁结合糖蛋白,大量存在于人乳汁和牛奶之中,并在哺乳动物和人体中广泛分布。长达70年的研究证实LF具有促进铁吸收、广谱抗菌、抗病毒、调节免疫等功能,是哺乳动物重要的营养成分之一。而新近的研究发现LF能在实验动物中抑制肿瘤生长和转移,并在人类的多种肿瘤中具有抑瘤基因的功能。作为一种天然的营养成分,LF的抑瘤功能使这个"旧"基因重新吸引了医学界的关注。Lactoferrin（LF） is an 80 kD iron-binding glycoprotein that is most highly produced in human and bovine milk and is also widely distributed in mammals.Researches of more than 70 years on lactoferrin prove that the molecule,as a nutritional molecule for mammals,possesses several physiological roles,including maintaining iron absorption,anti-microbial activity and immune modulation.Recent studies have demonstrated that LF can protect against cancer in experimental animals and has anticarcinogenic activity in many human tumors.As a natural nutrition,the ＂old＂ gene-lactoferrin has attracted attention from medical community for its ＂new＂anticarcinogenic role.

关 键 词：乳铁蛋白 肿瘤 抑瘤功能 

分 类 号：R730.2[医药卫生—肿瘤]