细胞DNA修复系统与肿瘤发生及化疗耐药性  

Relationship of DNA repair system with tumorigenesis and resistance to chemotherapy

作　　者：吕申[1] 

机构地区：[1]大连医科大学附属第二医院实验中心,辽宁大连116027

出　　处：《大连医科大学学报》2012年第6期519-524,共6页Journal of Dalian Medical University

基　　金：国家自然科学基金项目(81071805)

摘　　要：研究发现,MMR及MGMT蛋白表达缺失与大肠癌等恶性肿瘤的发生密切相关,胃癌及非小细胞肺癌常出现MMR和MGMT蛋白表达增高。本文通过介绍DNA修复系统中ERCC1、XRCC1和MMR、MGMT的作用机制及它们与肿瘤发生和化疗耐药性的关系,提出DNA修复系统关键蛋白的表达降低与肿瘤发生有关,在肿瘤发展过程中也会出现表达增高,且它们表达的增高或降低均与肿瘤化疗耐药性有关。Some researchers reported that the deficiency of MMR and MGMT proteins was associated with colorectal cancer and other cancers,and proteins of MMR and MGMT were over-expression in gastric cancer and non-small-cell lung cancer.This article introduces the mechanism of ERCC1,XRCC1,MMR,MGMT and the relationship with tumorigenesis and resistance to chemotherapy,and then suggests that hypo-expression of DNA repair proteins is associated with tumorigenesis and over-expression of them also appears in the development of tumors,and the abnormal expression is associated with resistance to chemotherapy.

关 键 词：ERCC1 XRCC1 MMR MGMT 肿瘤发生 化疗耐药 

分 类 号：R730.231[医药卫生—肿瘤]