早期给予膳食槲皮素对大鼠母代生殖及其子代生长发育的影响  

Effect of Prenatal Dietary Quercetin Supplementation on Female Rat Reproduction and Postnatal Development and Growth of Their Offspring

作　　者：李娜[1] 邢萌萌[1] 李文娟[2] 胡晓娟[1] 郑温雅[3] 聂少平[1] 

机构地区：[1]南昌大学 食品科学与技术国家重点实验室,江西南昌330047 [2]南昌大学 食品科学与技术国家重点实验室,江西南昌330047 [3]南昌大学食品科学与技术国家重点实验室,江西南昌330047

出　　处：《食品科学》2012年第23期297-300,共4页Food Science

基　　金：科技部国际合作项目(2010DFA31780)

摘　　要：目的:研究早期给予槲皮素对母鼠生殖及其子代发育的影响。方法:孕鼠随机分为4组:空白对照组、槲皮素低、中、高剂量组(从孕0d至断乳21d灌胃给予槲皮素,剂量分别为16、160、480mg/(kg.d))。定期检测母鼠和仔鼠的生长指标、繁殖能力、幼仔存活及幼仔肛殖距(AGD),产后第21天处死母鼠和仔鼠,计算母鼠和幼仔脏器指数。结果:与空白对照组相比,槲皮素组对母鼠体质量、繁殖能力、幼仔存活率没有影响;槲皮素低、中剂量组中雄性仔鼠AGD和体质量显著降低;槲皮素组对雌性仔鼠AGD和体质量没有影响;槲皮素高剂量组降低母鼠和雄性仔鼠的脾脏指数,中剂量组增加雌性仔鼠肾脏指数。结论:槲皮素具有雌激素及抗雌激素作用,对雄性仔鼠影响较大,无生殖与发育毒性。Objective： To investigate the effect of prenatal dietary quercetin supplementation on reproduction in female rats and the postnatal development and growth of their offspring.Methods： Pregnant SD rats were randomized into four groups： blank control and quercetin low,medium and high-dose groups.Quercetin was given by gavage to mice from gestation day 0 to postnatal day 21 at doses of 16,160 mg/（kg.d） and 480 mg/（kg.d）.and served as low,medium and high-dose groups,respectively.The mother rats and their offspring were examined for growth indices,reproductive capacity,and pup survival and anogenital distance（AGD） at regular time intervals during the administration period.At the end of the administration period,all of them were sacrificed and organ indices were measured.Results： Quercetin had no effects on maternal body weigh,reproductive capacity or pup survival as compared to blank controls.Quercetin administration at low and medium doses resulted in a significant decrease in AGD and body weight in male pups but had no effects on AGD or body weight in female pups.High-dose administration could reduce spleen index in mother rats and male pups,while female pups showed an increase in kidney index after medium-dose administration.Conclusion： Quercetin has estrogenic and anti-estrogenic activities,greater effects in male pups,but no reproductive and developmental toxicities.

关 键 词：槲皮素 生殖发育 围产期 

分 类 号：Q946.8[生物学—植物学]