过敏性哮喘大鼠模型的制备  

Establishment of Allergic Asthma Model in Rat

作　　者：崔龙苹[1] 杨永清[1] 陈汉平[1] 马淑兰[1] 张英英[1] 

机构地区：[1]上海市针灸经络研究所,上海200030

出　　处：《上海实验动物科学》2000年第2期69-71,共3页Shanghai Laboratory Animal Science

基　　金：国家自然科学基金!(39870 935);上海市教委资助项目!( 7C08)

摘　　要：为制备过敏性哮喘模型 ,腹腔注射卵蛋白致敏大鼠 ,2周后静脉内注射卵蛋白激发哮喘发作 ,应用“呼吸流量测定软件”测定气道阻力 (R)和肺顺应性 (C)。结果 :卵蛋白激发后大鼠气道阻力明显增加 ,肺顺应性明显降低 ,两者呈显著负相关关系。SD rats were intraperitoneally injected with ovabulmin. Two weeks later, the rats were intravenously challenged with ovalbumin, and the airway resistance, the pulmonary compliance were detected by breathe fluent analysis software. The results showed that after challenging with ovalbumin, airway resistance of the rats were significantly increased, and pulmonary compliance was obviously decreased after the challenge. The decrease of the pulmonary compliance was significantly correlated with the increment of the airway resistance. The results suggested that the allergic asthma model was successfully established. It is useful for researches on non-glucocorticoids immunosuppressive for asthma therapy ,as well as the mechanisms of glucocorticoids treatment in allergic asthma.

关 键 词：大鼠 过敏性哮喘 气道阻力 肺顺应性 动物模型 

分 类 号：R-332R361.2[医药卫生]