肾细胞癌转移潜能的分子学研究进展  

The Molecular Classification of metastatic renal carcinoma

作　　者：刘国栋[1] 刘晓[1] 

机构地区：[1]兰州大学第二医院泌尿外科研究所甘肃省泌尿系统疾病研究重点实验室甘肃省泌尿系疾病临床医学中心,甘肃兰州730030

出　　处：《现代泌尿外科杂志》2013年第1期1-3,共3页Journal of Modern Urology

摘　　要：在肾细胞癌中发现癌转移标志物,对确定癌转移危险性及选择新靶标治疗至关重要。现经PIQORTM微阵列研究证实,在透明细胞肾细胞癌(ccRCC)的非转移、早发转移和迟发转移癌间存在着明显的基因表达差异。应用这种差异,可知其转移可能性及早发或迟发转移,并制定出适合个性化的特殊治疗计划,使疗效更显著。The discovery of metastasis markers in clear cell renal cell carcinoma （ccRCC） is of critical importance to define individual metastatic risks and select patients for new targeted therapies. Recent studies by significance analysis of microarrays demonstrated differentially expressed genes between metastatic, nonmetastatic, early metastatic and late metastatic ccRCC. These data provide the possibility of defining the metastatic potential of ccRCC, based on a select number of genes, even in a localized situating and planning a specific individual therapy more effectively.

关 键 词：癌转移标志物 透明细胞肾细胞癌 微阵列分析 同时转移 异时转移 早发转移 迟发转移 基因表达 

分 类 号：R737[医药卫生—肿瘤]