2-位取代苯并呋喃类化合物的生物活性及合成研究进展  

Recent progress on biological activity and synthesis of 2-substituted Benzofuran derivatives

作　　者：陈焕[1] 李科[1] 

机构地区：[1]第二军医大学药学院药物化学教研室,上海200433

出　　处：《药学实践杂志》2013年第1期5-10,71,共7页Journal of Pharmaceutical Practice

摘　　要：苯并呋喃衍生物是当前研究杂环芳香族化合物的热点之一。据文献报道该类化合物具有抗肿瘤,抗氧化,钙内流阻滞,血管紧张素II受体拮抗,腺苷A1受体拮抗,抗真菌、抗菌活性和血小板聚集拮抗等药理作用。由于苯并呋喃具有广泛活性,因此吸引很多学者对其进行研究。为了更好地研究该类化合物的合成和生物活性,本文对近几年来文献报道的具有良好生物活性的2-位取代苯并呋喃衍生物进行综述,并对它们的合成方法进行概括,为开发新型2-取代苯并呋喃类化合物提供参考。Benzofuran derivatives were a series of attracting heterocyclic compounds with a variety of biological activity. Based on the recently published literatures, these derivatives had shown antitumor, antioxidant, calcium influx blockade, angiotensin II receptor antagonistic, adenosine A1 receptor antagonistic, antifungal, antibacterial and platelet aggregation antagonistic activities. As Benzofuran derivatives had broad activity, which had attracted many research interests. In order to better study of these corn- pounds both in synthesis and biological activity, the review focused on Benzofuran derivatives in recent years, which would provide valuable compounds. the biological activity and synthetic methods of 2-substituted information for the development of 2-substituted benzofuran

关 键 词：2-取代苯并呋喃 生物活性 合成方法 

分 类 号：R914[医药卫生—药物化学]