精神分裂症小世界神经网络研究进展(英文)  

Small-world brain networks in schizophrenia

作　　者：李名立 陈壮飞 李涛 

机构地区：[1]Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University [2]State Key Laboratory of Biotherapy, West China Hospital, Sichuan University [3]Faculty of Medicine, Kunming University of Science and Technology

出　　处：《上海精神医学》2012年第6期322-327,共6页Shanghai Archives of Psychiatry

基　　金：partly supported by National Natural Science Foundation of China (81130024, 30530300 and 30125014, TL);the National Basic Research Program of China (973 Program 2007CB512301, TL);the PhD Programs Foundation of the Ministry of Education of China (20110181110014, TL);National Key Technology R & D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan (2011BAZ02530, TL)

摘　　要：Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks - called 'small-world brain networks'- and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research.Over the last decade the combination of brain neuroimaging techniques and graph theoretical analysis of the complex anatomical and functional networks in the brain have provided an exciting new platform for exploring the etiology of mental disorders such as schizophrenia. This review introduces the current status of this work, focusing on the topological properties of human brain networks – called ‘small-world brain networks＇– and on the disruptions in these networks in schizophrenia. The evidence supporting the findings of reduced efficiency of information exchange in schizophrenia both within local brain regions and globally throughout the brain is reviewed and the potential relationship of these changes to cognitive and clinical symptoms is discussed. Finally we propose some suggestions for future research.

关 键 词：精神分裂症 网络图 小世界 大脑 患者 精神疾病 工作状态 拓扑性质 

分 类 号：R749.3[医药卫生—神经病学与精神病学] O157.5[医药卫生—临床医学]