Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage  

作　　者：Sumeng Liu Wu Liu Yaling Ma Kegao Liu Meizi Wang 

机构地区：[1]General Hospital of Ningxia Medical University [2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University [3]Beijing Ophthalmology & Visual Sciences Key Lab

出　　处：《Neural Regeneration Research》2012年第35期2770-2777,共8页中国神经再生研究（英文版）

摘　　要：Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1,2, and 4 weeks after injection. There was no difference between left （control） and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1,2, and 4 weeks after injection. There was no difference between left （control） and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.

关 键 词：nonsteroidal anti-inflammatory drug ketorolac tromethamine segment disease RETINA suprachoroidal space retinal toxicity ELECTRORETINOGRAPHY PHARMACOLOGY regeneration neuralregeneration 

分 类 号：R774[医药卫生—眼科]