Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder A proton magnetic resonance spectroscopy study  

作　　者：Osman zdel Demet Kalayci Gülfizar Szeri-Varma Yilmaz Kiroglu Selim Tümkaya Tuge Toker-Ugurlu 

机构地区：[1]Department of Psychiatry,Faculty of Medicine,Pamukkale University [2]Department of Psychiatry,Antalya Training and Research Hospital [3]Department of Radiology,Faculty of Medicine,Pamukkale University

出　　处：《Neural Regeneration Research》2012年第36期2929-2936,共8页中国神经再生研究（英文版）

基　　金：supported by Pamukkale University(Scientific Research Projects Coordination Unit)

摘　　要：The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.

关 键 词：bipolar disorder proton magnetic resonance spectroscopy medial prefrontal cortex N-asetylaspartate CHOLINE CREATINE DEGRADATION mood disorder neurochemical metabolite illness duration neural regeneration 

分 类 号：R749.4[医药卫生—神经病学与精神病学]