炭纤维细粉注入小鼠硬膜下的组织病理学研究  

HISTOPATHOLOGICAL STUDY ON FINE CARBON FIBER POWDER INJECTED INTO THE SUBDURAL SPACE OF MICE

作　　者：费克香[1] 彭先高[1] 高林[1] 马玲[1] 吴明灿[1] 孙维权[1] 

机构地区：[1]湖北省卫生职工医学院,湖北荆州434000

出　　处：《新型炭材料》2000年第2期39-42,共4页New Carbon Materials

摘　　要：将炭纤维细粉注入小鼠右颞侧硬脑膜下腔 ,动态观察其移动及组织病理学反应。结果 :注入后 1周～ 5 2周 ,未见实验组小鼠有与炭纤维植入有关的神经病学改变 ;其右颞侧硬膜内面及整个软脑膜表面 ,炭纤维呈弥散性分布 ;光学显微镜检查 ,炎细胞反应轻微 ,实验组注入后 1周 : 级 ,注入后 2周 : 级 ,注入后 4周 :0级 ,炎症反应基本消失 ;注入材料周围无明显纤维膜形成 ;实验组与同期对照组比较均无明显差异。结论 :炭纤维注入小鼠右颞侧的硬膜下腔和蛛网膜下腔后 ,表现出良好的组织相容性。After the fine carbon fiber powder was injected in to the right subdural space of the mice, dynamic observation was carried out on their movement and histopathological changes. Results: 1 52 weeks after the injecting, no neurological changes concerning with the implanting of the carbon fiber powder were found in the experimental mice. The fine carbon fiber extensively located on the inter surface of the dura mater membrane of the right temporalis and the out surface of pie mater. Only slight inflammatory cells reaction was found under optical microscopes. The experimental group: one week after injecting: GradeⅡ, two week: GradeⅠ, four weeks: Grade 0, the inflammatory reaction disappeared. No obvious fiber menbrane was found around the implanted materials. No significant differences were showed between the experimental group and the contrast group. Conclusion: It was showed that the carbon fiber shares excellent histocompatibility after the fine carbon fiber powder was injected into the subdural space and subarechnoid cavity of the right temple of mice.

关 键 词：炭纤维 组织病理学 小白鼠 医用材料 

分 类 号：R361.2[医药卫生—病理学]