单卵双胎同患慢性光化性皮炎四代一家系调查  

Both monovular twins suffered from chronic actinic dermatitis： a survey in a four-generation family

作　　者：杨永茂[1] 贾梅[2] 沈敏娟[3] 杨桂兰[4] 郝春梅[1] 潘凤军[1] 

机构地区：[1]内蒙古巴彦淖尔市医院皮肤科,015000 [2]内蒙古巴彦淖尔市医院心内科,015000 [3]江苏省吴江市第一人民医院皮肤科 [4]兰州军区兰州总医院皮肤科

出　　处：《中华皮肤科杂志》2013年第2期126-127,共2页Chinese Journal of Dermatology

摘　　要：目的探讨单卵双胎同患慢性光化性皮炎4代一家系发病情况及病变特征，明确其遗传关系。方法对先证者及其家族的临床资料、实验室检查进行分析。结果家系4代76名成员中共检出慢性光化性皮炎患者22例，其中男14例，女8例，有关的实验室检查及环境因素调查均为阴性。结论慢性光化性皮炎一家系调查中显示具有遗传性特性，符合常染色体显性遗传规律。Objective To investigate the clinical feature and prevalence of chronic actinic dermatitis in a four-generation family with both monovular twins affected by chronic actinic dermatitis. Methods The clinical and laboratory findings from monovular twins simultaneously affected by chronic actinic dermatitis and their four- family members were analyzed. Results There were 76 members in the four-generation family, with 22 members （including 14 males and 8 females） diagnosed with chronic actinic dermatitis. No positive results were found from laboratory examinations or environmental survey. Conclusion Chronic actinic dermatitis was inherited in an autosomal mode in this family.

关 键 词：慢性光化性皮炎 家系调查 单卵双胎 同患 实验室检查 四代 常染色体显性 病变特征 

分 类 号：R758[医药卫生—皮肤病学与性病学]