AGTR1基因多态性与糖尿病肾病易感性相关  

AGTR1 A1166C polymorphism is associated with risk of diabetic nephropathy

作　　者：尹雪瑶[1] 李红[1] 宣君丽[1] 陈怡馨[1] 李霖[1] 董雪红[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院内分泌科浙江省生物治疗重点实验室,浙江杭州310016

出　　处：《浙江大学学报（医学版）》2013年第1期45-51,共7页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省重大科技专项重点社会发展项目(2009C0310-4);国家科技支撑计划(2009BAI80B01)

摘　　要：目的:探讨Ⅰ型血管紧张素Ⅱ受体(angiotensinⅡtypeⅠreceptor,AGTR1)A1166C多态性与糖尿病肾病的关系。方法:用聚合酶链反应-限制性片段长度多态性技术研究AGTR1多态性在正常对照组(157例)、2型糖尿病非肾病组(141例,糖尿病病程≥10年)、2型糖尿病肾病组(152例)中的基因频率分布。结果:2型糖尿病肾病组AGTR1 C等位基因频率明显高于正常对照组和2型糖尿病非肾病组(P<0.05),正常对照组与2型糖尿病非肾病组间差异无统计学意义。结论:AGTR1 A1166C基因多态性与糖尿病肾病相关,即C等位基因携带可能增加糖尿病肾病的发生风险。Objective： To investigate whether the angiotensin II type I receptor gene （AGTR1） A1166C polymorphism is associated with a high risk of diabetic nephropathy. Methods： The allele frequency and the genotype distribution of the AGTR1 A1166C polymorphism were studied in normal controls （ 157 cases）, simple diabetes （ 141 cases, duration of diabetes ≥ 10 years）, and diabetic nephropathy （152 cases） by means of polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results： Patients with diabetic nephropathy had a higher frequency of C allele of the AGTRI A1166C polymorphism than that of normal controls and simple diabetes （P 〈 0.05） ; but there was no significant difference in frequency of C allele between the normal controls and patients with simple diabetes. Conclusion： The diabetic patients with AGTR1 C allele may be more susceptible to diabetic nephropathy than diabetic patients with A allele.

关 键 词：受体 血管紧张素 1型 遗传学 多态现象 遗传 糖尿病 2型 并发症 糖尿病肾病 遗传学 多态性 限制性片段长度 基因频率 等位基因 

分 类 号：R587.1[医药卫生—内分泌]