Annexin A1调控胰腺癌细胞迁移  

Annexin A1 regulation of pancreatic cancer cell migration

作　　者：汤晓东[1] 周家华[2] 

机构地区：[1]东南大学医学院附属江阴医院普外科,江苏江阴214400 [2]东南大学附属中大医院普外科,江苏南京210009

出　　处：《东南大学学报（医学版）》2013年第1期10-13,共4页Journal of Southeast University(Medical Science Edition)

基　　金：国家自然科学基金资助项目(30872500)

摘　　要：目的:鉴定Annexin A1胰腺癌细胞迁移中的作用。方法:构建Annexin A1的干扰质粒,筛选低转移细胞的干扰稳定细胞系。利用划痕实验及Transwell鉴定迁移能力。结果:Annexin A1表达的下调能促进低转移细胞的迁移能力。结论:Annexin A1抑制低转移胰腺癌细胞迁移能力。Objective： To explore the function of Annexin A1 in lower metastatic pancreatic cancer cells. Methods： Construct Annexin A1 RNAi plasmid and screen colo357 RNAi stable cell line. Wound healing and transwell assays were utilized to evaluate the migration ability. Results： Reduced Annexin A1 expression in lower metastatic pancreatic cancer cells promoted the migration. Conclusion： Annexin A1 regulates the motility of pancreatic cancer cells.

关 键 词：ANNEXIN A1 胰腺癌细胞 细胞迁移 

分 类 号：R-33[医药卫生] R329.28