肝肺综合征患者HIF-1α和MPO水平与门脉高压血流动力学的研究  

Relationship between HIF-1α, MPO and hemodynamic in patients with hepatopulmonary syndrome and portal hypertension

作　　者：戚秋藤[1] 王燕颖[1] 禹晶[2] 张秉全[2] 赵欣[1] 

机构地区：[1]黑龙江省医院消化内科,哈尔滨150036 [2]齐齐哈尔医学院第二附属医院消化内科,齐齐哈尔161005

出　　处：《中国肝脏病杂志（电子版）》2011年第1期8-11,共4页Chinese Journal of Liver Diseases：Electronic Version

基　　金：黑龙江省科技攻关项目(GB07C32506)

摘　　要：目的探讨彩色多普勒超声并对比增强超声心动图(CEE)评价肝肺综合征(HPS)肺内分流发生与血浆缺氧诱导因子-1α(HIF-1α)和髓过氧化物酶(MPO)以及门脉血流动力学变化的相互关系。方法利用彩色多普勒超声检测各组门静脉内径及血流速度,用CEE检测各组肺内分流,应用ELISA法分别检测健康者及伴与不伴HPS肝硬化患者的血浆HIF-1α和MPO浓度,对比各组血浆HIF-1α和MPO水平以及门脉血流动力学的变化与肺内分流程度的关系。结果 HPS组患者血浆HIF-1α和MPO浓度高于非HPS组,且门静脉内径增宽、血流速度减慢,两组结果比较差异有统计学意义(P<0.05),并与肺内分流程度呈正相关。结论彩色多普勒超声及CEE可以简便、敏感的反映血浆HIF-1α和MPO水平以及门静脉血流动力学异常在HPS发生中起一定作用,并可提示亚临床早期肺内血管异常。Objective To investigate the relationship between the color doppler sonography and contrast-enhanced echocardiography （CEE） in assessment of intrapulmonary shunting in patients with hepatopulmonary syndrome and HIF-1α, MPO and portal hemodynamic. Method The portal vein diameter and blood flow velocity were examined by color doppler, and intrapulmonary shunting by contrast-enhanced echocardiography （CEE）. Expressions of HIF-1α and MPO in serum were determined by ELISA in normal, hepatocirrhosis amalgamating HPS and unam algamating HPS patients, separately. HIF-1α and MPO levels were compared among the groups, also the portal hemodynamic and the intrapulmonary shunting were examined. Results The levels of HIF-1α and MPO in hepatocirrhosis amalgamating HPS levels patients were higher than those in unamalgamating HPS levels patients, the diameter of portal vein dilated and the velocity of portal vein dropped, which were statistically different between the two groups （P 0.05） and positively correlated with intrapulmonary shunting. Conclusions The color doppler sonography and contrast-enhanced echocardiography （CEE） which reflected HIF-1α, MPO levels patients and the hemodynamic played an role in the development of HPS, and was available to early examine the change of intrapulmonary vessel.

关 键 词：超声检查 多普勒 彩色 缺氧诱导因子-1 过氧化物酶 肝肺综合征 

分 类 号：R575.2[医药卫生—消化系统]