顺铂联合金葡素或香菇多糖治疗恶性胸腔积液导致发热的差异分析  

Analysis of Differences of Fever Caused by Cisplatin Combined with Staphylococcin or Lentinan in Malignant Pleural Effusion

作　　者：王守峰[1] 张金岭[1] 殷忠美[1,2] 李明[1] 张云[1] 张峰[1] 

机构地区：[1]山东大学附属临沂市人民医院肿瘤科,山东临沂276000 [2]泰山医学院,山东泰安271000

出　　处：《肿瘤基础与临床》2013年第1期54-56,共3页journal of basic and clinical oncology

摘　　要：目的分析顺铂联合金葡素或香菇多糖胸腔内灌注治疗恶性胸腔积液导致发热差异的原因。方法将经病理证实的恶性胸腔积液患者52例随机分为2组(A组和B组),胸腔内分别灌注顺铂联合金葡素或香菇多糖,3 d后2组交换灌注药物行第2次胸腔内灌注,对比观察2次患者发热的情况。结果第1次胸腔内灌注后,顺铂联合金葡素发热率(56.00%)高于顺铂联合香菇多糖(11.11%)(P=0.000 6);第2次胸腔内灌注后,顺铂联合金葡素发热率(55.56%)高于顺铂联合香菇多糖(32.00%),但差异无统计学意义(P=0.087 5)。同组患者前后2次应用顺铂联合金葡素或香菇多糖后,A组发热率顺铂联合金葡素高于顺铂联合香菇多糖,但差异无统计学意义(P=0.087 4);B组发热率顺铂联合金葡素高于顺铂联合香菇多糖(P=0.000 5)。结论顺铂联合金葡素胸腔内灌注治疗恶性胸腔积液造成发热率较顺铂联合香菇多糖高,可能由于顺铂损伤胸膜上皮屏障功能后金葡素中的内毒素等致热原大量入血所致。Objective To analyze the differences of fever caused by cisplatin combined with staphylococcin or lentinan in malignant pleural effusion. Methods Fifty-two patients with malignant pleural effusion were divided into group A and group B, and were given with intrapleural infusion of cisplatin p]us staphylococcin or cisplatin plus len- tinan respectively. Three days later, the drugs of perfusion are interchanged between group A and group B. Results After the first infusion, the fever rate of cisplatin plus staphylococcin （56.00%） were higher than that of cisplatin plus lentinan （ 11.11% ） （ P = 0.000 6 ） ; after the second infusion, the fever rate of cisplatin plus staphy]ococcin （55.56%） were higher than that of cisplatin plus lentinan （32.00%） , but there was no statistical difference be- tween the cisplatin plus staphylococcin and the cisplatin plus lentinan （ P = 0. 087 5 ）. In the same group the cisplatin plus staphylococcin or the cisplatin plus lentinan were given one after another, the fever rate of cisplatin plus staphylococcin was still higher than that of cisplatin plus lentinan in group A, but there was no statistical difference between the cisplatin plus staphylococcin and the cisplatin plus lentinan （ P = 0. 087 4） ; the fever rate of cisplatin plus staphylococcin was still higher than that of cisplatin plus lentinan in group B （P = 0. 000 5）. Conclusion The fever rate of cisplatin plus staphylococcin in the treatment of malignant pleura/effusion is higher than that of cispla- tin plus lentinan; the possible reason is that cisplatin injuries pleura and ability of barrier is descent, endotoxin in staphylococcin ingress into blood through injuried pleura.

关 键 词：顺铂 香菇多糖 金葡素 发热 肺癌 胸腔积液 

分 类 号：R734.2[医药卫生—肿瘤]