Stereospecific Synthesis of Drospirenone  

作　　者：Gang Deng Zuogang Huang Xiaolong Zhao Zheng Li Yuanchao Li Biao Jiang 

机构地区：[1]Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China [3]Department of Medicinal Chemistry, Shanghai Institute ofMateria Medica, Chinese Academy of Sciences, Shang- hai 201203, China

出　　处：《Chinese Journal of Chemistry》2013年第1期15-17,共3页中国化学（英文版）

基　　金：Acknowledgement This research was financially supported in part by the China Postdoctoral Science Foundation and the Na- tional Basic Research Program of China （Nos. 2010CB833200, 2010CB833300）, the National Natural Science Foundation of China （Nos. 20832007, 21102167）, the Science and Technology Commission of Shanghai Municipality （No. 12DZ1930902） and the Knowledge Innovation Program of Chinese Academy of Sciences. We thank Zhejiangshenzhou Pharmaceutical Co., Ltd for providing starting materials.

摘　　要：A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiary alcohol reduction system, and the tandem oxidation/cyclopropanation reactions.A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiary alcohol reduction system, and the tandem oxidation/cyclopropanation reactions.

关 键 词：DROSPIRENONE stereospecific synthesis ionic hydrogenation Oppenauer oxidation CYCLOPROPANATION 

分 类 号：TQ922[轻工技术与工程—发酵工程] O625.12[理学—有机化学]