supported by the National Natural Science Foundation of China(Nos.42177367,41877063,and U1901601);the National Key Research and Development Programof China(No.2019YFC1804400);the Central Government Fund Supporting Non-profit Scientific Institutes for Basic Research and Development(No.PM-zx703-202112-332).
Altrenogest(ALT),drospirenone(DRO),and melengestrol acetate(MLA)are three highly potent synthetic progestins that can be released into agricultural soils,while their fate in soil minerals remains unclear.This study ex...
supported by Beijing Municipal Administration of Hospitals'Ascent Plan of China(No.DFL20181401).
Objective:To investigate the effects of orlistat combined with drospirenone/ethinylestradiol tablets(DRSP/EE)on anthropometric indices,sexual hormones,hepatorenal function parameters of overweight or obese patients wi...
This study aimed to estimate the risk of venous thromboembolism(VTE),arterial thromboembolism(ATE),and other side effects following the use of drospirenone(DRSP)-containing combined oral contraceptives(COCs).When comp...
Objective: To explore the effect of tibolone as well as Estradiol and Drospirenone replacement therapy on the neurohumoral indexes and immune function in perimenopausal women. Methods: A total of 180 perimenopausal wo...
Background:While combined oral contraceptives (COCs) are commonly used to treat polycystic ovary syndrome (PCOS),comparative data regarding metabolic effects of different progestogens on this patient population a...
Aim: We assessed bleeding pattern, tolerance and patient satisfaction of an oral contraceptive containing 3 mg drospirenone and 30 mcg ethinyl estradiol (DRSP/EE) under real-life conditions. Study Design: We performed...
Acknowledgement This research was financially supported in part by the China Postdoctoral Science Foundation and the Na- tional Basic Research Program of China (Nos. 2010CB833200, 2010CB833300), the National Natural Science Foundation of China (Nos. 20832007, 21102167), the Science and Technology Commission of Shanghai Municipality (No. 12DZ1930902) and the Knowledge Innovation Program of Chinese Academy of Sciences. We thank Zhejiangshenzhou Pharmaceutical Co., Ltd for providing starting materials.
A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C7-tertiary alcohol with ZnI2/Et3SiH, a novel mild and stereospecific tertiar...