云南高校图书馆联盟文献共享服务平台- ORLISTAT

ORLISTAT: 作品数：24被引量：28H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郑以漫项坤三任建东米婷婷刘诗雨更多>>; 相关机构：中国海洋大学上海交通大学附属第六人民医院安徽医科大学成都军区总医院更多>>; 相关期刊：《Journal of Chemistry and Chemical Engineering》《合成化学》《Journal of Bio-X Research》《Pharmacology & Pharmacy》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划四川省科技厅科技支撑计划项目更多>>

Inhibitory effect of procyanidin B2 and tannin acid on cholesterol esterase and their synergistic effect with orlistat被引量：2: 《Food Science and Human Wellness》2024年第1期360-369,共10页Xiangxin Li Yijing Pu Haitao Jiang Wenxiao Jiao Wenjun Peng Wenli Tian Weibo Jiang Xiaoming Fang; supported by the National Basic Research Program of China(‘973’program,2013CB127106)。; This study was aimed to analyze the effect of procyanidin B2(PC)and tannin acid(TA)on the activities of cholesterol esterase(CEase)and the inhibitory mechanisms of enzymatic activity.The interaction mechanisms were in...; 关键词：Cholesterol esterase POLYPHENOLS Interaction mechanisms Molecular dynamic simulation Synergistic effect

Advanced therapy of overweight or obese polycystic ovary syndrome:a prospective study被引量：3: 《Global Health Journal》2022年第2期75-79,共5页Min Min Xiangyan Ruan Alfred O.Mueck; supported by Beijing Municipal Administration of Hospitals'Ascent Plan of China(No.DFL20181401).; Objective:To investigate the effects of orlistat combined with drospirenone/ethinylestradiol tablets(DRSP/EE)on anthropometric indices,sexual hormones,hepatorenal function parameters of overweight or obese patients wi...; 关键词：Overweight/Obese Polycystic ovary syndrome ORLISTAT Drospirenone/ethinylestradiol tablets

Orlistat induces ferroptosis-like cell death of lung cancer cells被引量：4: 《Frontiers of Medicine》2021年第6期922-932,共11页Wenjing Zhou Jing Zhang Mingkun Yan Jin Wu Shuo Lian Kang Sun Baiqing Li Jia Ma Jun Xia Chaoqun Lian; supported by grants from the National Natural Science Foundation of China(No.81672314);the Key Natural Science Project of Anhui Provincial Education Department(No.KJ2020A1244,KJ2020A0578,and KJ2018A0221);National Innovation Program for College Students(Nos.201810367021 and 201710367036).; Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers,including lung cancer;however,targeting the lipogenetic pathways for cancer therapy remains an unmet cl...; 关键词：ORLISTAT ferroptosis FAF2 lung cancer

Effect of orlistat on obese women with polycystic ovary syndrome被引量：1: 《Journal of Bio-X Research》2018年第3期128-131,共4页Qi Jiang Yuhua Shi; supported by the National Key Research and Development Program of China(No.2017YFC1001004);National Natural Science Foundation of China(No.81471428);Special Funds for Taishan Scholar Engineering,China(No.ts201712103).; Polycystic ovary syndrome(PCOS)is a common gynecological endocrine syndrome characterized by metabolic abnormality and reproductive dysfunction,including ovulation abnormality,hyperandrogenism and polycystic ovarian m...; 关键词：HYPERANDROGENISM insulin resistance OBESITY ORLISTAT polycystic ovary syndrome pregnancy outcome

Light and Electron Microscopic Study of the Effect of Orlistat on the Liver of Adult Male Albino Rats and the Possible Protective Role of <i>β</i>-Carotene: 《Forensic Medicine and Anatomy Research》2018年第2期20-36,共17页Sahar Youssef; Orlistat is a safe and effective drug to treat obesity by acting as a pancreatic and gastric lipase inhibitor, resulting in reduction in fat absorption. There is also concern that it may be linked with an increased th...; 关键词：LIVER ORLISTAT Ultrastructure Β-CAROTENE

计算机辅助设计新型人脂肪酸合酶抑制剂及其抗肿瘤活性: 《合成化学》2016年第12期1038-1042,共5页刘诗雨米婷婷任建东范开华何菱; 国家自然科学基金资助项目(21072131);四川省科技厅科技支撑计划资助项目(2015SZ0168); 以Orlistat为先导化合物,利用Auto Dock进行计算机模拟对接,在对接结果中选择能量较低的6个结构进行合成与抗肿瘤活性筛选。以orlistat为原料,经2步反应制得苄基(2S,3S,5S)-2-己基-3,5-二羟基十六酸酯(2);再经4步反应获得(3S,4S)-3-己基...; 关键词：ORLISTAT 计算机辅助药物设计抗肿瘤活性合成人脂肪酸合酶抑制剂

Orlistat-lnduced Modulation of Plasma Metabolites Independent of Weight Loss in Overweight Females: 《Journal of Chemistry and Chemical Engineering》2013年第6期547-555,共9页Thiago I. B. Lopes Lucas G. Martins Sabrina Nagassaki Bruno Geloneze Anita Jocelyne Marsaioli; Orlistat-induced weight loss results in amelioration in several comorbidities including obesity-related dyslipidemia. The aim of the present study was to characterize the changes in the blood plasma metabolic profile ...; 关键词：tH NMR METABONOMICS LACTATE EDTA calcium.

Lipase Inhibitor from Fruits of <i>Solanum stramonifolium</i>Jacq.被引量：1: 《Food and Nutrition Sciences》2013年第5期554-558,共5页Watinee Chanmee Chanya Chaicharoenpong Amorn Petsom; Obesity is usually considered as an overweight or excess body fat, leading to increased health problems. Obesity is a major risk factor for a number of serious diseases. Decreasing dietary fat absorption, through inhi...; 关键词：SOLANUM stramonifolium Jacq. LIPASE INHIBITOR Carpesterol ORLISTAT Obesity

Comparative Pharmacokinetic Study between Metformin Alone and Combined with Orlistat in Healthy Mexican Volunteers: 《Pharmacology & Pharmacy》2012年第3期300-306,共7页Noemí Santos-Caballero Francisco Javier Flores-Murrieta; Traditional treatment of type 2 diabetes mellitus (T2DM) has focused on correcting hyperglycemia. However, T2DM is almost always accompanied by other conditions and risk factors that affect its morbidity and mortality...; 关键词：METFORMIN ORLISTAT Diabetes Obesity BIOEQUIVALENCE PHARMACOKINETIC

The Effectiveness of Watermelon Endocarp Extract in Inhibiting Lipase Activity Relative to the Hypolipidemic Drugs: 《Journal of Life Sciences》2011年第7期541-545,共5页Subandi Hambali Indah Langitasari; In the effort to prove the effectiveness of watermelon endocarp extract as a hypolipidemic, the authors have done an initial experiment of lipase inhibition with the extract. The puposes of this study are to evaluate...; 关键词：Watermelon endocarp a lipase inhibitor orlistat.

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