Abiotic transformation of synthetic progestins in representative soil mineral suspensions  

作　　者：Xingjian Yang Rui Wang Zhili He Xiong Dai Xiuping Jiang He Liu Yongtao Li 

机构地区：[1]College of Natural Resources and Environment,Joint Institute for Environment&Education,South China Agricultural University,Guangzhou 510642,China [2]State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment,South China Institute of Environmental Science,Ministry of Ecology and Environment,Guangzhou 510655,China

出　　处：《Journal of Environmental Sciences》2023年第5期375-388,共14页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.42177367,41877063,and U1901601);the National Key Research and Development Programof China(No.2019YFC1804400);the Central Government Fund Supporting Non-profit Scientific Institutes for Basic Research and Development(No.PM-zx703-202112-332).

摘　　要：Altrenogest(ALT),drospirenone(DRO),and melengestrol acetate(MLA)are three highly potent synthetic progestins that can be released into agricultural soils,while their fate in soil minerals remains unclear.This study explored the transformation of these progestins in MnO_(2),SiO_(2),and ferrihydrite suspensions and identified their transformation products(TPs)via high resolution mass spectrometry and density functional theory calculations.Transformations were only observed for DRO and MLA in SiO_(2) suspension and ALT in MnO_(2) suspension(half-lives=0.86 min–9.90 day).ALT transformation was facilitated at higher MnO_(2) loadings,while DRO and MLA transformations were inhibited at higher SiO_(2) loadings.These data indicated that hydrophobic partitioning interactionwas dominant at higher SiO_(2) loadings rather than specific interaction,which limited subsequent surface-catalyzed transformation.ALT transformation rate decreased with increasing pH because MnO_(2) reduction requires proton participation.In contrast,relatively high pH facilitated MLA and DRO transformation,indicating that base-catalyzed hydrolysis occurred in SiO_(2) suspension.The clustermap demonstrated the formation of abundant TPs.Lactone ring and acetoxy group hydrolysis was the major transformation pathway for DRO and MLA,with estimated yields of 57.7%and 173.2%at 6 day,respectively.ALT experienced C12 hydroxylation and formed the major TP 326g(yield of 15.4%at 8 hr).ALT also experienced allyl group oxidation and subsequent C5 hydroxylation,forming the major TP 344a(yield of 14.1%at 8 hr).This study demonstrates that TPs ofmetastable progestins are likely the main species in soils and that TP identification is a particular priority for risk assessment.

关 键 词：ALTRENOGEST DROSPIRENONE Melengestrol acetate Transformation products Hydrolysis Oxidation 

分 类 号：X131.3[环境科学与工程—环境科学]