A Clear-Cut Synthesis of Arteannuin O  

作　　者：Huijun Chen Hongdong Hao Yikang Wu 

机构地区：[1]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2013年第1期139-142,共4页中国化学（英文版）

基　　金：Acknowledgement This work was supported by the National Basic Research Program of China （the 973 Program, 2010CB833200）, and the National Natural Science Foundation of China （Nos. 21172247, 21032002, 20921091, 20621062）.

摘　　要：The title compound was synthesized from dihydroqinghao acid via a sequential facial selective oxidative lac- tonization and epoxidation, a molybdenum-catalyzed perhydrolysis of the epoxy ring and dimethyl sulfide reduction of the hydroperhydroxyl functionality. Some explorations on the lactonization and ring-opening of the epoxide along with data discrepancy found with the epoxy intermediate are also presented.The title compound was synthesized from dihydroqinghao acid via a sequential facial selective oxidative lac- tonization and epoxidation, a molybdenum-catalyzed perhydrolysis of the epoxy ring and dimethyl sulfide reduction of the hydroperhydroxyl functionality. Some explorations on the lactonization and ring-opening of the epoxide along with data discrepancy found with the epoxy intermediate are also presented.

关 键 词：DIOL OXIDATION EPOXIDE perhydrolysis RING-OPENING 

分 类 号：TQ223.26[化学工程—有机化工] Q946.8[生物学—植物学]