导管持续引流心包积液联合香菇多糖心包腔内灌注治疗肺癌导致恶性心包积液临床研究  

The clinical research on catheter constant drainage combined with pericardial perfnsion lentinan for malignant pericardial effusion caused by lung cancer

作　　者：姜雪滨[1] 宋芳华[1] 单丹妮[1] 尹晓芹[1] 

机构地区：[1]大连大学附属新华医院肿瘤内科,116021

出　　处：《中国医师进修杂志》2013年第6期1-3,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的观察导管持续引流心包积液联合香菇多糖心包腔内灌注对肺癌导致恶性心包积液的疗效及不良反应。方法选择118例经病理学或细胞学检查证实为肺癌并导致恶性心包积液患者，按照随机数字表法分为治疗组56例与对照组62例，治疗组患者行中心静脉导管持续引流后接受香菇多糖心包腔内灌注；对照组患者行中心静脉导管持续引流后接受顺铂心包腔内灌注，比较两组疗效及不良反应。结果治疗组有效率89．3％（50／56），对照组有效率83．9％（52／62），两组比较差异无统计学意义（χ^2=0．736，P=0．391）。治疗组不良反应发生率[8．9％（5／56）]低于对照组[24．2％（15／62）]，差异有统计学意义（χ^2=4．871，P=0．027）。治疗组与对照组复发率比较差异无统计学意义[14．3％（8／56）比11．3％（7／62）]（χ^2=0．004，P=0．948）。结论导管持续引流心包积液联合香菇多糖心包腔内灌注治疗肺癌导致恶性心包积液安全、有效，可作为肺癌导致恶性心包积液的首选治疗方法。Objective To evaluate the effect and safety of catheter constant drainage combined with pericardial perfusion lentinan in treatment of patients with malignant pericardial effusion caused by lung cancer. Methods One hundred and eighteen patients with malignant pericardial effusion caused by lung cancer were divided into 2 groups by table of random digit,the treatment group （56 cases） was treated by perieardial perfusion lentinan after catheter constant drainage by central venous catheter,and the control group （62 cases） was treated by pericardial perfusion cisplatin after catheter constant drainage by central venous catheter. The therapeutic effect and adverse reaction were contrasted between the two groups. Results There was no significant difference in effective rate between treatment group and control group [89.3% （50/56） vs. 83.9% （52/62）, χ^2 =0.736,P =0.391]. The adverse reaction rate of treatment group was significantly lower than that of control group [ 8.9% （ 5/56 ） vs. 24.2% （ 15/62 ）, χ^2 = 4.871, P = 0.027 ]. There was no significant difference in recurrence rate between treatment group and control group [ 14.3%（8/56） vs. 11.3% （7/62）, χ^2 = 0.004,P = 0.948 ]. Conclusions Catheter constant drainage combined with pericardial perfusion lentinan for malignant pericardial effusion caused by lung cancer is safety and effective, and can be widely applied to clinical application.

关 键 词：心包 引流术 恶性心包积液 香菇多糖 

分 类 号：R730.5[医药卫生—肿瘤]