马铃薯糖苷生物碱抗真菌活性构效关系研究  

Structure-antifungal activity relationships of potato glycoalkaloids

作　　者：赵雪淞[1] 李盛钰[2] 何大俊[2] 王娟[2] 

机构地区：[1]辽宁工程技术大学矿业学院,辽宁阜新123000 [2]东北师范大学生命科学学院,吉林长春130024

出　　处：《食品工业科技》2013年第6期159-163,共5页Science and Technology of Food Industry

基　　金：高等学校博士学科点专项科研基金(20070200004)

摘　　要：采用平板菌丝生长抑制法测定了马铃薯糖苷生物碱茄碱和查茄碱、其酸水解产物β1-查茄碱、β2-查茄碱、γ-查茄碱和β2-茄碱及其硫酸化产物6-O-硫酸查茄碱和6-O-双硫酸茄碱的抗真菌活性,分析了糖链组成和结构与其活性的关系。结果表明,糖链的单糖组成、连接方式、连接顺序和单糖数目等对化合物的生物活性均有重要影响。Potato glycoalkaloids oz-chaconine and α-solanine,the acid-hydrolysis products ,β1-chaconine,β2- chaconine,γ-chaconine and β2-solanine,and the 6-O-sulfated products 6-O-sulfated chaconine and 6-0- disulfated solanine was examined for their percent inhibition on radial growth of fungi using an agar dilution method,and then,the structure-antifungal activity relationships of them was analyzed. Results indicated that the nature,order and number of attachment of the carbohydrate residues of potato glycoalkaloids could strongly influence the antifungal activity.

关 键 词：马铃薯糖苷生物碱 查茄碱 茄碱 抗真菌活性 构效关系 

分 类 号：TS201.6[轻工技术与工程—食品科学]