迷迭香提取物对高脂血症小鼠血脂的影响  

Effect of rosemary extracts on hyperlipemia of mice induced by high fat diet

作　　者：张泽生[1] 康海轩[1] 王婷婷[1] 韩顺凯[1] 邢学辉[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《食品科技》2013年第3期197-200,205,共5页Food Science and Technology

基　　金：国家科技支撑技术计划项目(2012BAD33B05)

摘　　要：目的:探讨迷迭香提取物的降血脂功效。方法:将雄性C57BL/6小鼠随机分为5组,分别饲喂基础饲料(正常组)、高脂饲料(模型组)和添加质量分数为0.25%、0.5%、1%迷迭香提取物的高脂饲料(剂量组),12周后,采集血清及各组织样本,检测血脂相关指标。结果:饲喂高脂饲料可成功建立高血脂动物模型,迷迭香提取物可有效降低高脂膳食小鼠血清中总胆固醇(TC)、甘油三酯(TG)、非高密度脂蛋白胆固醇(non-HDL-C)含量及动脉粥样硬化指数(AI),提高HDL-C含量,肝脏中TC、TG含量也有显著性降低,同时血清和肝脏中MDA生成下降,抗氧化酶活性提高。结论:迷迭香提取物可有效降低小鼠的血脂水平,预防并减少动脉硬化的发生,提高血清及肝脏的抗氧化水平。Objective： To explore the effect of rosemary extracts on lowering blood lipid. Methods： The male C57BL/6 mice were divided into 5 groups, including the control group fed with a basal diet, model group given with a high-fat diet and three intervention groups administered with rosemary extracts at does of 0.25%, 0.5% and 1.0%. Twelve weeks later mice were sacrificed, collected the serum and tissue for testing. Results： the high-fat model was found in the mice fed the diet containing high lipid. The TC, TG, non-high density lipoprotein cholesterol （non-HDL-C） and the value of atherosclerosis index （AI） in serum could be decreased significantly in the hyperlipidemic mice by rosemary extracts. The HDL-C in serum could be increased. The TC, TG in liver could also be decreased. Furthermore, MDA contents in serum and liver were deceased, and liver were decreased, and activities of antioxidant enzymes were increased. Conclusion： rosemary extracts has an obvious effect on lowering blood lipid, Preventing and reducing the incidence of atherosclerosis, increasing the antioxidant activities of serum and liver, Among them the group at dose of 1% showed the best effect.

关 键 词：迷迭香 高血脂 小鼠 降血脂 抗氧化 

分 类 号：TS201.4[轻工技术与工程—食品科学]