国内唐氏综合征产前筛查及诊断研究文献计量分析  

Bibliometic analysis on the prenatal screening and diagnosis of Down’s syndrome in China

作　　者：陈云香[1] 王书平[2] 王坤[3] 惠文[1] 李雪[1] 吴华章[1] 

机构地区：[1]中国医科大学人文社科学院,辽宁沈阳110001 [2]卫生部卫生发展研究中心,北京100191 [3]华中科技大学,湖北武汉430074

出　　处：《中国实用妇科与产科杂志》2013年第3期208-211,共4页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的系统分析国内关于唐氏综合征产前筛查和产前诊断研究的文献,为制定适合我国国情的产前筛查方案提供参考。方法以"唐氏综合征"或"DS"、"产前筛查"和"产前诊断"为主题词,对中国期刊全文专题数据库等的文献进行检索,检索年限为1987-2012年。并对符合纳入标准的文献进行数据提取和统计分析。结果检索到符合纳入标准的文献90篇。统计分析结果显示我国产前筛查的策略主要是孕中期的血清学二联筛查,产前诊断的取样方法主要是羊膜腔穿刺,诊断方法主要为染色体核型分析。结论选择合适的筛查策略及截断值是目前产前筛查的重要研究方向,增加筛查指标及采用孕早期联合筛查将是我国未来产前筛查的趋势。Objective To systematically analyze the domestic articles about prenatal screening and diagnosis of down ~s syndrome and provide basis for formulating new prenatal screening plan suitable for current conditions in China. Methods We searched the full text databases of China with subject terms containing ＂ down＇s syndrome＂/＂ DS＂, ＂prenatal screening＂ and ＂prenatal diagnosis＂ and defining the published year between 1987 and 2012. After that, the data from the articles meeting the criteria was extracted and analyzed statistically. Results Totally 90 articles were included in the study. Statistical analysis showed that the strategy of prenatal screening in China is mainly in the second-trimester with se- rological double marker screening, prenatal diagnosis sampling method is mainly amniocentesis （AC）, diagnosis methods mainly the analysis of the chromosome karyotypes. Conclusions Choosing appropriate screening strategies and truncation value are currently important research directions of prenatal screening, increasing the screening indexes and screening in the first-trimester will be the trend of prenatal screening in the future in China.

关 键 词：唐氏综合征 产前筛查 产前诊断 文献计量分析 

分 类 号：R714.55[医药卫生—妇产科学]