高同型半胱氨酸血症与认知损害的关系研究  

Study of relationship between hyperhomocysteinemia and cognitive impairment

作　　者：杨增云[1] 张兰娥[1] 卢国华[1] 何冰[1] 范静波[1] 

机构地区：[1]潍坊医学院护理学院,山东潍坊261053

出　　处：《中国医药科学》2013年第6期13-14,31,共3页China Medicine And Pharmacy

基　　金：山东省自然科学基金资助项目(ZR2010HM042)

摘　　要：目的探讨高同型半胱氨酸血症(hyper-homocysteinemia,Hhcy)与认知损害的关系并探明引起认知损害的机制。方法采用酶联免疫分析法(ELISA)检测30名MCI患者和45名正常老年人的血清同型半胱氨酸(Hcy)、S-腺苷甲硫氨酸(SAM)和S-腺苷同型半胱氨酸(SAH)的浓度。结果 MCI组血清Hcy浓度(31.03±12.42)μmol/L、SAH浓度(6.63±1.72)μmol/L与正常组相比差异有统计学意义(P<0.01)。SAM浓度(80.10±12.13)μmol/L及MMSE评分(25.45±1.22)分均低于正常组,差异有统计学意义(P<0.01)。同时MCI组Hcy浓度与SAM浓度及MMSE评分均呈负相关,与SAH浓度呈正相关(r=-0.61、-0.57、0.62,P<0.05)。结论血清Hcy、SAM和SAH浓度与轻度认知功能障碍具有相关性,Hcy通过抑制甲基化进程影响认知损害。Objective To investigate the relationship between hyperhomocysteincmia （Hhcy） and cognitive impairment and verify the mechanism of causing cognitive impairrnernt.Methods The concentrations of serum homocysteine （Hcy）, S-adenosylmethionine （SAM） and S-adenosylhomocysteine （SAH） of 30 MCI patients and 45 normal old people were measured using the enzyme-linked immunosorhent assay （ELISA）. Results The serum Hcy concentration （31.03 ± 12.42）μ mol/L and SAH concentration （6,63± 1.72） μL mol/L of the MCI group were significantly different from those of the normal group （P 〈 0.01）. The SAM concentration （80.10 ±12.13）μmol/L and MMSE score （25.45± 1.22）points of the MCI group were both lower than thnse of the normal group （P 〈 0.01）. Meanwhile, in the MCI group, Hcy concentration and SAM concentration were negatively correlated to MMSE score, hut positively correlated to SAH concentration （r=-0.61, -0.57, 0.62, P 〈 0.05）. Conclusion Serum Hcy, SAM and SAH concentrations have relevance to mild cognitive impairment and Hhcy affects cognitive impairment through inhibiting the methylation process.

关 键 词：高同型半胱氨酸血症 轻度认知功能障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]