男性主动攻击行为与D2S1338、D19S433基因座的关联研究  

Association study of the genetic polymorphism of D2S1338 and D19S433 loci and the initiative-aggressive behavior in male population

作　　者：杨春[1] 巴华杰[2] 余海鹰[1] 高志勤[1] 赵汉清[1] 过伟[1] 

机构地区：[1]解放军第102医院精神科,常州213003 [2]常州市公安局刑警支队DNA室

出　　处：《中华行为医学与脑科学杂志》2013年第2期127-130,共4页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨男性主动攻击行为与D2S1338、D19S433基因座的关联情况。方法采用PCR结合毛细管电泳的方法对江苏地区187例男性主动攻击行为者（研究组）和459例健康男性（对照组）的外周静脉血样进行D2S1338、D19S433基因座的基因型分析，并根据两组在D2S1338、D19S433基因座的等位基因及基因型分布差异来推测与主动攻击行为相关的易感因素和（或）抗性因素。结果D2S1338、D19S433基因座均符合遗传平衡定律（Hardy—Weinberg定律）；研究组和对照组在D19S433基因座上的等位基因及基因型频率分布差异均存在统计学意义（P〈0．05），在D2S1338基因座上的等位基因及基因型频率分布差异均无统计学意义（P〉0．05）。单因素分析显示两组在D19S433基因座的等位基因14．2及基因型14—14的频率分布差异均有统计学意义（P=0．0011，P：0．0008），OR值分别为0．50（95％CI：0．33～0．76）、3．49（95％CI：1．62—7．52）。结论D19S433基因座可能与主动攻击行为的发生相关联，该基因座的等位基因14．2为主动攻击行为的保护因素，而基因型14—14为主动攻击行为的易感因素。Objective To investigate the relationship of the initiative-aggressive behavior and D2S1338, D19S433 loci. Methods PCR and eleetrophoresis method were used to conduct genotype analysis on D2S1338 and D19S433 in the peripheral blood of 187 male initiative-aggressive violent offenders and 459 healthy men living in Jiangsu area. Results D2S1338 and D19S433 loci in initiative-aggressive behavior group and ilealthy group were found to coincide with Hardy-Weinberg equilibrium （P 〉 0.05 ）. There were significant difference in locus D19S433 （P 〈 0.05 ）between initiative-aggressive behavior group and healthy group, but not on locus D2S1338 （P〉 0.05 ）. Univariate analysis showed significant differences at allele 14.2 and genotype 14-14 on locus D19S433 be-tween the two groups（P=0.0011, P=0. 0008） with the OR values being 0.50（ 95% CI ：0.33-0.76 ）and 3.49 （95% CI ：1.62-7.52 ）, respectively. Conclusion Locus D19S433 may be related to with initiative-aggressive be-havior with allele 14.2 being the resistant factor and genotype 14-14 being the susceptible factor.

关 键 词：主动攻击行为 染色体 人 微卫星重复 多态现象 遗传 病例对照研究 

分 类 号：R749[医药卫生—神经病学与精神病学]