44例经腹绒毛活检产前诊断的应用分析  

44 cases of transabdominal chorionic villus biopsy applied analysis.

作　　者：邓璐莎[1] 郭晓玲[1] 钟进[1] 陈建仪[1] 朱晓丹[1] 伍秋艳[1] 

机构地区：[1]广东省佛山市妇幼保健院,528000

出　　处：《中国优生与遗传杂志》2013年第3期76-77,82,共3页Chinese Journal of Birth Health & Heredity

基　　金：广东省佛山市卫生局科研项目(项目编号:2011166)

摘　　要：目的对经腹绒毛活检在产前诊断中的应用分析。方法选择2010年1月至2011年12月在我院产检门诊就诊有产前诊断指征的单胎孕妇44例,经知情同意后行经腹绒毛活检,同时选择同时期有产前诊断指征的行脐静脉穿刺的单胎孕妇50例进行比较,分别计算其手术成功率及妊娠丢失率。结果 44例经腹绒毛活检术的孕妇中,检查出染色体异常4例,一例18-三体,2例21-三体,1例45,XO,重型α地贫5例,均引产。其中1例术后3天胎死宫内,染色体确诊为21-三体。其余追踪观察至分娩,无出现胎盘血肿、胎盘剥离、阴道流血、胎儿结构畸形等,手术成功率100%,妊娠丢失率为2.27%,与同期经腹脐静脉穿刺术相比,P>0.05,差异无统计学意义,尚不能认为两种方法的手术成功率及妊娠丢失率不等。但脐静脉穿刺一般需要在妊娠22w后进行,故经腹绒毛活检能在早期及时发现,减少孕妇的情感和心理压力。结论孕早期绒毛活检术具有早诊断、准确性高、并发症少的优点,是一种安全、准确可靠的产前诊断技术。Objective： Analysize the transabdominal chorionic villus biopsy in prenatal diagnosis.Methods： Selected 44 cases with single fetus in 2010 January to 2011 December in our hospital out-patient examination with the indications for prenatal diagnosis of informed consent by transabdominal chorionic villus biopsy,and selected the same period with the indications for prenatal diagnosis of umbilical vein puncture line of singleton pregnancies in 50 cases were compared,respectively to calculate its operation success rate and pregnancy loss rate.Results： 44 cases of abdominal cashmere wool biopsy in pregnant women,check out the chromosomal abnormality in 4 cases,a case of trisomy 18,2 cases of trisomy 21,1 cases with 45,XO,5 cases were severe α-thalassemia,induction of labor.Among it,1 patient with fetal death in utero after transabdominal chorionic villus in 3 days,which of chromosome diagnosed trisomy 21.The remaining track until birth,without placental hematoma,placental abruption,vaginal bleeding,fetal structural abnormalities,operation success rate of 100%,pregnancy loss rate of 2.27%,compared to abdominal umbilical vein puncture,P0.05,the difference was not statistically significant,can not think of two methods of operation success rate and pregnancy loss rate unequal.But the umbilical vein puncture in general need after 22 weeks of pregnancy,the transabdominal chorionic villus biopsy in early and timely discovery,pregnant women to reduce the emotional and psychological pressure.Conclusion： Early pregnant chorionic villi biopsy with early diagnosis,high accuracy,less complications,is a safe,accurate and reliable prenatal diagnostic techniques.

关 键 词：经腹绒毛活检 产前诊断 染色体 地中海贫血 手术成功率 妊娠丢失率 

分 类 号：R714.55[医药卫生—妇产科学]