乙酰基二茂铁缩氨基硫脲的合成及其电化学行为和抑菌活性  

Synthesis,electrochemical behaviors and antimicrobial activities of acetylferrocene thiosemicarbazone

作　　者：吴校彬[1] 郝卫东[2] 

机构地区：[1]黄冈师范学院化学与生命科学学院,经济林木种质改良与资源综合利用湖北省重点实验室,湖北黄州438000 [2]黄冈师范学院化工学院,湖北黄州438000

出　　处：《化学试剂》2013年第4期379-381,384,共4页Chemical Reagents

摘　　要：以二茂铁为原料合成了乙酰基二茂铁缩氨基硫脲(AFT),其结构通过IR、1HNMR和元素分析予以确证。测定了AFT乙腈溶液的循环伏安图。测试了AFT二甲亚砜溶液的抑菌活性。循环伏安实验表明,在-0.30～0.83 V的扫描范围内,AFT出现氧化还原峰;当扫描速度为100～500 mV/s,其半波电位(E1/2)为0.569～0.559 V;氧化峰电流(Ipa)与还原峰电流(Ipc)比值为1.855～1.420,且Ipa、Ipc均与扫描速度平方根(ν1/2)呈线性关系。抑菌试验表明,AFT对金黄色葡萄球菌有抑菌作用,抑菌圈直径为14 mm,抑菌最低浓度为167μg/mL。Acetyl ferrocene thiosemicarbazone（AFT） was synthesized via two-reaction steps using ferrocene as a precursor.The structure was confirmed by IR,1HNMR and elementary analysis.The electrochemical behavior and antimicrobial activity of AFT were investigated in anhydrous acetonitrile solution and in dimethylsulfoxide solution,respectively.The result of cyclic voltammetry showed that AFT exhibited a pair of redox wave in the scan rang of-0.30～0.83 V with a half-wave potential（E1/2）at 0.569～0.559 V.The ratio of Ipa/Ipc was 1.855～1.420,and the peak current（Ipa and Ipc） was observed to be linearly proportional to the square root of scan rates（ν1/2） with the scan rate from 100 to 500 mV/s.The antimicmbial results indicated that AFT possessed a good antimicrobial activity against S.Aureus.

关 键 词：二茂铁 缩氨基硫脲 合成 循环伏安 抑菌活性 

分 类 号：O626[理学—有机化学]