清音丸改剂型前后对免疫低下模型小鼠作用的比较研究  

A Comparative Study of the Qingyin Bolus and Qingyin Tablet Which Formulations were Changed from Qingyin Bolus on Immunocompromised Mouse Model

作　　者：李雪梅[1] 周建平[1] 胡宇驰[1] 

机构地区：[1]北京市药品检验所,100035

出　　处：《首都医药》2013年第6期61-63,共3页Capital Medicine

摘　　要：目的比较清音丸由蜜丸改为片剂后对免疫低下模型小鼠作用的变化。方法取ICR小鼠,随机分成9组:空白对照组,模型对照组,参芪颗粒,清音丸和片大、中、小剂量组(按生药量计,0.910g/kg,0.455g/kg,0.228g/kg),连续给药14d,观察比较清音丸、清音片对腹腔注射环磷酰胺所致免疫低下模型小鼠网状内皮系统单核巨噬细胞的吞噬功能以及对鸡红细胞所致小鼠特异性抗体的生成有无明显促进作用;二硝基氯苯致小鼠迟发型超敏反应试验,连续给药12d后观察小鼠T淋巴细胞转化为致敏淋巴细胞反应情况。结果清音丸、清音片具有增强小鼠网状内皮系统吞噬功能及增强体液免疫功能的作用。两种剂型药效对细胞免疫无明显差异,但从数值上看清音片略优于清音丸。结论清音丸由蜜丸剂型改为片剂后对非特异性免疫和体液免疫都有增强作用。Objective Compare the efficacy of Qingyin tablet whose formulations changed form the Qingyin Bolus and Qingyin Bolus for immunocompromised mouse model of role. Method ICR mice were randomly divided into blank group,model group,ShenQi keli,Qingyin Bolus and Qingyin tablet high,medium and low-dose group（0.910g/ kg,0.455g/kg,0.228g/kg） administered orally 14 days.Compare reticuloendothelial system monocyte-macrophage cell phagocytic function on immuncompromised mouse model whoes were injected cyclophosphamide by intraperitoneal and specific antibodies generation which caused by chicken red blood cells in Immunocompromised mouse model.After 12 days of continuous administration,observe the response of mouse T lymphocytes into the sensitized lymphocytes in Dinitro-chlorobenzene induced delayed-type hypersensitivity test.Result Qingyin Bolus and Qingyin tablet can enhaced reticuloendothelial system phagocytic function and enhanced humoral immune function.Two dosage forms efficacy of cellular immunity was no significant difference,but from the numerical point of view,Qingyin tablet is slightly better than Qingyin Bolus.Conclusion Qingyin tablet which changed from Qingyin Bolus had enhanced non-specific immunity and humoral immunity.

关 键 词：清音丸 清音片 改剂型 增强免疫 

分 类 号：R969.4[医药卫生—药理学]